Results 91 to 100 of about 7,813,805 (354)

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Feasibility of radical cardiac‐sparing, treatment planning strategies for patients with locally advanced, non‐small cell lung cancer

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose A set of treatment planning strategies were designed and retrospectively implemented for locally advanced, non‐small cell lung cancer (NSCLC) patients in order to minimize cardiac dose without compromising target coverage goals. Methods Retrospective analysis was performed for 20 NSCLC patients prescribed to 60–66 Gy that received a ...
Joshua P. Kim, Jake Dewalt, Aharon Feldman, Khaled Adil, Benjamin Movsas, Indrin J. Chetty   +5 more
wiley   +1 more source

A general framework for quantifying the effects of land-use history on ecosystem dynamics

, 2019
Land-use legacies are important for explaining present-day ecological patterns and processes. However, an overarching approach to quantify land-use history effects on ecosystem properties is lacking, mainly due to the scarcity of high-quality, complete ...
Blondeel, Haben, Depauw, Leen, Kopecký, Martin, Landuyt, Dries, Maes, Sybryn, Máliš, František, Perring, Michael, Vanhellemont, Margot, Verheyen, Kris   +8 more
core   +1 more source

ASTRONAUT SELECTION AND POTENTIAL RISK MANAGEMENT: PSYCHOLOGICAL TRAUMA AND RESILIENCE FOR MARS SPACE MISSION [PDF]

Trames
The first human orbited the Earth for less than two hours in 1961. The twelve Apollo astronauts experienced up to 22 hours of walking on the Moon (Apollo 17).
David W. Kim
doaj   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

COMP Report: CPQR technical quality control guidelines for use of positron emission tomography/computed tomography in radiation treatment planning

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Positron emission tomography with x‐ray computed tomography (PET/CT) is increasingly being utilized for radiation treatment planning (RTP). Accurate delivery of RT therefore depends on quality PET/CT data. This study covers quality control (QC) procedures required for PET/CT for diagnostic imaging and incremental QC required for RTP.
Ran Klein, Mike Oliver, Dan La Russa, John Agapito, Stewart Gaede, JeanPierre Bissonnette, Arman Rahmim, Carlos Uribe   +7 more
wiley   +1 more source

Backpedaling Toward Plessy [PDF]

, 2007
When the Supreme Court overturned two desegregation plans, the majority opinion was based on a distortion of both programs, and of the history of desegregation in ...
Lowe, Robert
core   +1 more source

Testing general relativity and probing the merger history of massive black holes with LISA

, 2004
Observations of binary inspirals with LISA will allow us to place bounds on alternative theories of gravity and to study the merger history of massive black holes (MBH). These possibilities rely on LISA's parameter estimation accuracy. We update previous
, Alessandra Buonanno, Baker J Centrella J, Bender P L, Clifford M Will, Danzmann K, Emanuele Berti, Haehnelt M G, Hughes S A, Koushiappas S M Zentner A R, Merritt D Milosavljević M, Rhook K J Wyithe J S B, Will C M   +12 more
core   +3 more sources

JOHN OF SALISBURY’S “SUMMA SCIENTIAE”: AUTHOR AND THE TEXTS IN CULTURE OF THE “RENAISSANCE OF THE TWELFTH CENTURY”

Вестник Мининского университета, 2017
The paper is dedicated on detail consideration of two types of John of Salisbury’s works (1115/1120-1180) - the big one including treatises “Entheticus de dogmate philosophorum”, “Policraticus”, “Metalogicon” and the small one, which involves two "Lifes"
A. K. Gladkov
doaj   +2 more sources

Critique of weakly decohering and linearly positive histories [PDF]

arXiv, 1994
The usual composition rule of independent systems, as applied to decoherent histories or to linearly positive histories, requires (at least) medium decoherence and, consequently, a second constraint for the linearly positive histories of Goldstein and Page.
arxiv