Results 121 to 130 of about 17,748,027 (382)

REVIEW to: Francisco Gómez Martos, La creación de una historia nacional. Juan de Mariana y el papel de la Antigüedad en la Edad Moderna, Madrid: Dykinson, 2018, pp. 272 (ISBN 978-8491485476) [PDF]

open access: yesTalia dixit, 2018
Review to La creación de una historia nacional. Juan de Mariana y el papel de la Antigüedad en la Edad Moderna (Anejos de la Revista de Historiografía nº 8).
Joaquín Villalba Álvarez
doaj  

Featured Piece

open access: yes, 2017
This year the General Editors decided to create a feature piece to show our appreciation for the History Department. We selected four professors from the faculty to answer a question about history: what figure/event/idea inspires your interest in history?
Hancock, Scott   +3 more
core  

The Ideal Whole Health Family Oriented Community Center [PDF]

open access: yes, 2012
This paper discusses what would make up the ideal whole health family oriented community center. It looks at the history of community centers in a general manner, and it looks at three existing community centers in New Hampshire.
St. Germain, Jessica
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

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