Results 51 to 60 of about 50,288 (215)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Enriched biodiversity data as a resource and service
Biodiversity Data Journal, 2014 Background: Recent years have seen a surge in projects that produce large volumes of structured, machine-readable biodiversity data. To make these data amenable to processing by generic, open source “data enrichment” workflows, they are increasingly ...
Rutger Vos +34 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Enzymes, Ideas and People: The Department of Enzymology of the Institute of Biochemistry of the Romanian Academy [PDF]
Memoirs of the Scientific Sections of the Romanian AcademyThis paper outlines the history of the Department of Enzymology at the Institute of Biochemistry of the Romanian Academy. A leading centre in Romania, the department is recognised for its long-standing contributions to the study of enzymes and their ...
Otilia Cristina Donțu +1 more
doaj
High-up: a remote reservoir of microbial extremophiles at Central Andean Wetlands
Frontiers in Microbiology, 2015 The Central Andes region displays unexplored ecosystems of shallow lakes and salt flats at mean altitudes of 3,700 m. Being isolated and hostile, these so-called High-Altitude Andean Lakes (HAAL) are pristine and have been exposed to little human ...
Virginia Helena Albarracín +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Antípoda: Revista de Antropología y ArqueologíaExtractivist archaeological practices have been carried out in the Atacama Lickanantay territory, Antofagasta region, northern Chile, ever since the 19th century, excluding or denying the voice and/or participation of members of the local indigenous ...
Patricia Ayala +3 more
doaj +1 more source
A unified framework for managing provenance information in translational research
BMC Bioinformatics, 2011 Background A critical aspect of the NIH Translational Research roadmap, which seeks to accelerate the delivery of "bench-side" discoveries to patient's "bedside," is the management of the provenance metadata that keeps track of the origin and history of ...
Sahoo Satya S +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source