Results 41 to 50 of about 1,254,121 (350)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Introduction to Heritage Assets: 19th- and 20th-Century Convents and Monasteries [PDF]

open access: yes, 2014
A short description of the history and architecture of English nineteenth and twentieth-century convents and monasteries, with an emphasis on their most significant ...
Brittain-Catlin, Timothy
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Few Words Suffice: Banister Fletcher, the Architectures of Ancient America, and 19th Century French and British Historiographies

open access: yesLes Cahiers de la Recherche Architecturale, Urbaine et Paysagère
This study aims to illuminate the pivotal role of ancient American civilizations in the development of European architectural historiography. During the second half of the 19th century, with special emphasis on France and Great Britain, the new knowledge
Horacio Caride Bartrons
doaj   +1 more source

Surveying for architectural students: as simple as possible – as much as necessary [PDF]

open access: yesISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
More and more, existing buildings – and particularly historic buildings – are becoming part of the daily business of every architect. Planning and designing in the field of architectural heritage requires not only knowledge of contemporary ...
I. Mayer, T. Mitterecker
doaj   +1 more source

The Relationship Between Enslaved Individuals And Plantation Architecture In 18th And 19th Century Virginia [PDF]

open access: yes, 2020
The Relationship Between Enslaved Individuals And Plantation Architecture In 18th And 19th Century Virginia Emma Clark, Depts. of History and Anthropology, with Dr. Bernard K. Means, Dept.
Clark, Emma
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Landscape History and Theory: from Subject Matter to Analytic Tool [PDF]

open access: yes, 2004
This essay explores how landscape history can engage methodologically with the adjacent disciplines of art history and visual/cultural studies.
Birksted, Jan Kenneth
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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