Results 231 to 240 of about 636,262 (305)

Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory–Validation Study

Annals of Neurology, EarlyView.
Objective Lactate is increasingly recognized as an energy substrate, but its relevance to amyotrophic lateral sclerosis (ALS) remains unclear. We examined whether blood lactate is associated with survival and weight loss in ALS. Methods This retrospective study included an Australian exploratory cohort and a Japanese validation cohort with clinical ...
Ryutaro Nakamura, Frederik J. Steyn, Shuhei Kobashi, Nobuhiro Ogawa, Akihiro Kitamura, Isamu Yamakawa, Robert D. Henderson, Shyuan T. Ngo, Makoto Urushitani   +8 more
wiley   +1 more source

Adolf Nichtenhauser and the history of medical film. [PDF]

Med Hist
Cantor D.
europepmc   +1 more source

Does non-random segregation of DNA-strands occur during stem cell division in Macrostomum lignano? [PDF]

, 2008
Borgonie, Gaetan, De Mulder, Katrien, Ladurner, Peter, Mouton, Stijn, Verdoodt, Freija, Willems, Maxime   +5 more
core   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, EarlyView.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

'Name It to Tame It': Dementia Diagnostic Procedure in Austrian Care Facilities for People With Intellectual Disabilities. An Interview Study. [PDF]

J Intellect Disabil Res
La Face A, Pendl D, Gasteiger-Klicpera B.   +2 more
europepmc   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Consequences of Medium‐Pore Zeolite Constraints for Alkene Cracking—The Case of n‐Pentene

Angewandte Chemie, EarlyView.
Alkene cracking in medium‐pore zeolites is governed by a balance of enthalpic and entropic effects. Intrinsic barriers are quantified and shown to be lower than for alkanes due to stabilization of carbenium‐ion‐like transition states. Confinement and extra‐framework aluminum modulate reactivity by tuning transition‐state energetics, providing a ...
Ruixue Zhao, Stefan Schallmoser, Gary L. Haller, Maricruz Sanchez‐Sanchez, Johannes A. Lercher   +4 more
wiley   +1 more source

Long-Term Young Adult Cancer Survivors with Ovarian Cancer: Subgroup Analysis of the Study "Expression VI-Carolin Meets HANNA-Holistic Analysis of Long-Term Survival with Ovarian Cancer": The International NOGGO, ENGOT, and GCIG Survey. [PDF]

Cancers (Basel)
Dimitrova D, Samartzis EP, Zocholl D, Barretina-Ginesta MP, Leitner K, Havelka P, Achimas-Cadariu P, Taskiran C, Mittelstadt S, Van Nieuwenhuysen E, Bauerschmitz G, Heinzelmann-Schwarz V, Madariaga A, Ringsdorf U, Zwimpfer T, Madroñal C, Enzinger HM, Al Rubaish S, Sehouli J, Woopen H.   +19 more
europepmc   +1 more source

Case Report: COVID-19 unmasks factor H mutation-driven hemolytic uremic syndrome in a previously undiagnosed septuagenarian kidney transplant recipient. [PDF]

Front Med (Lausanne)
Fink M, Pollheimer M, Kirsch A, Rosenkranz AR, Eller K, Schuller M.   +5 more
europepmc   +1 more source