Results 141 to 150 of about 1,652,481 (345)

Heidegger’s Black Noteboooks: National Socialism. Antisemitism, and the History of Being [PDF]

open access: yes, 2017
This chapter examines: (1) the Black Notebooks in the context of Heidegger's political engagement on behalf of the National Socialist regime and his ambivalence toward some but not all of its political beliefs and tactics; (2) his limited "critique" of ...
Nelson, Eric S.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Catholicism and anti-communism: the reactions of Irish intellectuals to revolutionary changes in Hungary (1918-1939)

open access: yesDiacronie. Studi di Storia Contemporanea, 2018
Although far from the centres of conflict on the Continent, interwar Ireland was also exposed to the influence of extreme left and right-wing political movements. Overall, most Irish nationalists adopted an uncompromisingly anti-Communist stance and used
Lili Zách has received her Masters Degrees in English (with specialization in Irish Studies) and History at the University of Szeged, Hungary, in 2006. She completed a PhD at the National University of Ireland, Galway, focusing on Irish perceptions of the small successor states of Austria-Hungary, 1914-1945. Her primary research interest lies in the field of Irish and Central European history in a transnational framework, with special attention to Irish links with Continental Europe in the first half of the twentieth century.
doaj  

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

The Ambassador, Between Light and Shade : The Emergence of Secrecy as the Norm of International Negotiation [PDF]

open access: yes
The aim of this research paper is to analyse to what extent secrecy emerged as the uncontested norm for international negotiations after the Renaissance. The first section (1) introduces six key negotiation practitioners in 17th century Europe, including
Colson, Aurélien
core   +1 more source

New Labour? The Impact of Migration from Central and Eastern European Countries on the UK Labour Market [PDF]

open access: yes
The UK was one of only three countries that granted free movement of workers to accession nationals following the enlargement of the European Union in May 2004.
Lemos, Sara, Portes, Jonathan
core   +3 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

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