Results 121 to 130 of about 3,445,482 (314)

From Völkerpsychologie to Cultural Anthropology: Erich Rothacker’s Philosophy of Culture [PDF]

open access: yes, 2020
Erich Rothacker (1888–1965) was a key figure in early-twentieth-century philosophy in Germany. In this paper, I examine the development of Rothacker’s philosophy of culture from 1907 to 1945.
Steizinger, Johannes
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Insomnia: a cultural history [PDF]

open access: yesThe Lancet, 2018
Whitehead, Kimberley, Beaumont, Matthew
openaire   +4 more sources

Sex and Sexuality in the United States: A Brief History of Culture Wars [PDF]

open access: yes, 2011
The HIV/AIDS pandemic has entered its thirtieth year; sex trafficking persists as an $8 billion industry (May 2006); unwanted pregnancies and transmission of sexually transmitted infections (STIs) continuously occur due to a lack of simple knowledge ...
Marcus, Olivia
core   +2 more sources

The Secwepeme Museum and History [PDF]

open access: yes, 2020
The Secwepeme Museum and Heritage Park in Kamloops is the first native-owned and operated museum to be developed in the interior of British Columbia. The museum derives its mandate from the Shuswap Declaration of 1982, an agreement signed by the 17 bands
Favrholdt, Ken
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The historiography of Nixon’s 1972 visit to China

open access: yesCogent Social Sciences
This article investigates the historiography of Richard Nixon’s 1972 visit to China, examining how scholars’ interpretations of the event have evolved.
Yong Wang, Li Li, Syed Tahir Abbas
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

[Review of] Gretchen M. Bataille and Kathleen M. Sands. American Indian Women, Telling Their Lives [PDF]

open access: yes, 1985
American Indians are not conquered. The heart of the American Indian woman is not on the ground. In taking over the control of the telling of her life, she preserves the reality and meaning of tribal history and culture.
Scott, Carol J.
core   +1 more source

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