Results 131 to 140 of about 3,445,482 (314)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Dress Behind Bars: Prison Clothing as Criminality [PDF]

, 2009
Research for this sole-authored book was undertaken during AHRC-funded Research Leave (2007). It represents Ash’s expertise as a dress historian and interest in the history and current organisation of prisons, which evolved from her teaching experience ...
Ash, Juliet
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Digging in or building bridges? A scoping review of thematic analysis

Frontiers in Research Metrics and Analytics
This scoping review deals with a major trend in qualitative data analysis: thematic analysis (TA) that provides a general framework to develop relatively transparent processes; TA thus helps mitigate long-standing concerns with allegedly subjective ...
Christian Herzog, Christian Handke, Erik Hitters   +2 more
doaj   +1 more source

Contextualising the microbiota-gut-brain axis in history and culture. [PDF]

Microb Ecol Health Dis, 2019
Moore AM, Mathias M, Valeur J.
europepmc   +1 more source

Poland in Times of Great War and Second Independence 1914–1939 [PDF]

, 2015
The present book “Poland – History, Culture and Society. Selected Readings” is the third edition of a collection of academic texts written with the intention to accompany the module by providing incoming students with teaching materials that will assist ...
Pietrzak, Jacek
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Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Kola Peninsula Neolithic

Археология евразийских степей
The archaeology of the Kola Peninsula is related to the archaeology of neighboring regions. The Early Neolithic (~5.3–4 millennia BC) is characterized by the Säräisniemi 1 ceramics of the two Varzina and Chavanga variants and the Pit-Comb, bifacial stone
Evgeniy M. Kolpakov, Alevtina M. Kiseleva, Anton I. Murashkin, Vladimir Ya. Shumkin   +3 more
doaj   +1 more source

Fearless: Lhagyai Trichen

, 2014
Humble about his successes and origins, driven by a desire to serve his countrymen and raise awareness about their struggles and identity, and involved in opening dialogues about the issues facing his home country of Tibet, Lhagyari Trichen ’17 ...
Trichen, Lhagyari
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