Results 81 to 90 of about 3,421,831 (294)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The River God Cult and the Reshaping of Political Authority—Reading Inscriptions from the Hezhong Area in Tang China

Religions
The River God cult held a significant place in state rituals in imperial China. While scholars have primarily focused on the evolution of the River God sacrificial system, with its interplay of the official granting of noble titles and popular beliefs ...
Aihua Jiang, Longxiang Ma
doaj   +1 more source

Globalization and Chinese Contemporary Art: West to East, East to West [PDF]

, 2017
In this article, Carter tells the weaving tale of the globalization of art and the interplay between eastern and western contemporary art. Carter sketches out the history of contemporary art in China with a keen eye towards the interplay between Chinese ...
Carter, Curtis L.
core   +1 more source

From Völkerpsychologie to Cultural Anthropology: Erich Rothacker’s Philosophy of Culture [PDF]

, 2020
Erich Rothacker (1888–1965) was a key figure in early-twentieth-century philosophy in Germany. In this paper, I examine the development of Rothacker’s philosophy of culture from 1907 to 1945.
Steizinger, Johannes
core  

HISTORY OF ENGLISH CULTURE

, 2023
The way of life of England is from time to time sensitive to split effortlessly from the way of life of the United Kingdom, so influential has English way of life been at the societies of the British Islands and, on the opposite hand, given the quantity to which different societies have informed lifestyles in England.
Dushatova Shohsanam Baxtiyor Qizi, Do'smatova Begoyim Husanboy Qizi   +1 more
openaire   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Key aspects of the basic provisions of the legislative acts concerning the reform of the Ukrainian culture at the time of formation of the State of independence

Проблеми Законності, 2015
Problem Setting. The article examines the Soviet heritage in the culture of independent Ukrain be late 80s early 90s of the XX century. The main aspects of the first legislative acts concerning the reform of the Ukrainian culture are analyzed, namely ...
Г. В. Скрипчук
doaj   +1 more source

Research on the Communication Strategy of History and Culture in Shaanxi Based on BP Neural Network Model. [PDF]

Comput Intell Neurosci, 2022
Xie D, Yin C.
europepmc   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source