Results 161 to 170 of about 599,885 (312)

Constitutional <i>BRCA1</i> Promoter Methylation in Patients With Ovarian Cancer: Results of the Observational AGO-TR1 Study. [PDF]

JCO Precis Oncol
Kayali M, Hahnen E, Burges A, Reuss A, Caro-Valenzuela J, de Gregorio N, Heitz F, Schmidt S, Marmé F, Hilpert F, Wimberger P, Kommoss S, Prieske K, Engel C, Buderath P, Dietrich D, Schmutzler R, Sehouli J, Rhiem K, Harter P, Hauke J.   +20 more
europepmc   +1 more source

Banking systems and economic growth: lessons from Britain and Germany in the pre-World War I era [PDF]

Banks and banking - History ; Banks and banking - Germany ; Banks and banking - Great Britain ; Germany ; Great ...
Caroline Fohlin
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Does an app make patients happy? Impact of a novel medical history app on patient satisfaction in urgent care consultations in Germany: cluster-randomized interventional trial 'DASI'. [PDF]

BMC Health Serv Res
Noack EM, Antweiler K, Müller F, Schröder D, Friede T, Hummers E, Roddewig L.   +6 more
europepmc   +1 more source

A multilevel event history analysis of the effects of grandmothers on child mortality in a historical German population [PDF]

We analyzed data from the historic population of the Krummhörn (Ostfriesland, Germany, 1720-1874) to determine the effects of grandparents in general and grandmothers in particular on child mortality.
Eckart Voland, Jan Beise
core  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

On the crossroads of interdisciplinary medicine in amyloidosis - study protocol for a single-center interdisciplinary registry study. [PDF]

PLoS One
Pernice H, Barzen G, Piwowarski J, Muratovic-Colic H, Pankow A, von Landenberg-Roberg V, Bohl S, Schrezenmeier E, Wetzel PJ, Wieder NW, Fiß G, Blüthner E, Knebel F, Messroghli D, Werhahn SM, Gröschel J, Maier AB, Schönfeld S, Wetz C, Schulz-Menger J, Heidecker B, Nogai A, Spethmann S, Hahn K.   +23 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Murder in East Germany: A Most Puzzling Case

An investigation of how murder was investigated and publicised in East Germany, given the fact that the East German regime claimed that - thanks to socialist societal conditions - there was no serious crime in the country.N/
Millington, Richard
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source