Results 171 to 180 of about 599,885 (312)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Towards clinically interpretable machine learning in emergency surgery: feature importance and insights across clinical time points in abdominal pain cases. [PDF]

Langenbecks Arch Surg
Henn J, Hatterscheidt S, Nesic S, Nowak S, Block W, Röttgen J, Gräff I, Kalff JC, Sprinkart AM, Buness A, Matthaei H.   +10 more
europepmc   +1 more source

The population history of Germany: research strategy and preliminary results [PDF]

The paper presents the project of an aggregative reconstruction of the population of Ger-many from the sixteenth century to 1840, when official statistics began to provide complete coverage of all German states.
Georg Fertig, Ulrich Pfister
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Genomics as a time capsule: insights from Oreobates chiquitanus type specimens. [PDF]

BMC Genomics
Schöneberg Y, Nebenführ M, Jansen M, Janke A, Winter S.   +4 more
europepmc   +1 more source

History Made in Germany [PDF]

Nature, 1934
openaire   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Polymorphic Skin Rash and Fatigue in a Patient with Diabetes Mellitus: A Quiz. [PDF]

Acta Derm Venereol
Yilmaz K, Winkler M, Misiraj B, Lammers K, Géraud C.   +4 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Detection of previously undiagnosed conditions in midlife preventive health examinations. [PDF]

Sci Rep
Kalski L, Hafermann L, Pulst Caliman TJ, Greiß F, Karathanos A, Pächter C, Herrmann C, Wolfarth B.   +7 more
europepmc   +1 more source