Results 21 to 30 of about 733,507 (305)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Toponomastics in Great Britain (20th–21st Centuries): History and Main Directions of Research [PDF]

Вопросы ономастики, 2013
The paper offers a review of toponymic research in England and, partially, in other regions of the United Kingdom. The author analyzes the forms of organization of research communities, their activities and main scientific projects (notably, those of the
Vladislav V. Alpatov
doaj  

THE IMAGE OF RUSSIAN EMPERORS ON THE PAGES OF SCOTLAND QUARTERLY BOOK REVIEW THE EDINBURGH REVIEW IN THE FIRST QUARTER OF THE XIX CENTURY

Гуманитарные и юридические исследования, 2021
N the first quarter of the XIX century, the international situation in Europe contributed to the increased interest to the Russian Empire from the audience of European newspapers and magazines.
Vladimir Eremin
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Cultural Haunting and the Trace of the Colonial Other in Arthur Conan Doyle's Short Fiction [PDF]

, 2017
In Home Truths: Fictions of the South Asian Diaspora in Britain (2002), Susheila Nasta argues that “the arrival in Britain of several generations of black and Asian 'immigrants' in the period following decolonization and Independence was not simply the ...
Martín-González, Juan-José
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Revision of the types of species of Alloxysta described by Cameron and Fergusson (Hymenoptera: Figitidae: Charipinae) and deposited in the Natural History Museum (London), including a key to the fauna of Great Britain [PDF]

, 2013
Type material of the species of Alloxysta described by Cameron and Fergusson and deposited in the Natural History Museum of London has been revised. Seven species are considered valid: Alloxysta abdera Fergusson, 1986, A.
Ferrer-Suay, Mar, Notton, David G., Pujade-Villar, Juli, Selfa, Jesús   +3 more
core   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Applying the anisotropy of magnetic susceptibility technique to the study of the tectonic evolution of the West Spitsbergen Fold-and-Thrust Belt

Polar Research, 2016
We demonstrate the use of the anisotropy of magnetic susceptibility (AMS) method to determine the orientation of the principal tectonic strain directions developed during the formation of the West Spitsbergen Fold-and-Thrust Belt (WSFTB).
Katarzyna Dudzisz, Rafał Szaniawski, Krzysztof Michalski, Geoffrey Manby   +3 more
doaj   +1 more source

'How compliant do we want to be with the colonoscopy surveillance guidelines?'

, 2007
Objective: To assess the referral practice for surveillance colonoscopy amongst clinicians and to measure whether practice was inline with the current Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of ...
Basnyat, P.S., Chivers, K.C., Taffinder, N.   +2 more
core   +1 more source