Results 31 to 40 of about 730,997 (307)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Toponomastics in Great Britain (20th–21st Centuries): History and Main Directions of Research [PDF]

Вопросы ономастики, 2013
The paper offers a review of toponymic research in England and, partially, in other regions of the United Kingdom. The author analyzes the forms of organization of research communities, their activities and main scientific projects (notably, those of the
Vladislav V. Alpatov
doaj  

THE IMAGE OF RUSSIAN EMPERORS ON THE PAGES OF SCOTLAND QUARTERLY BOOK REVIEW THE EDINBURGH REVIEW IN THE FIRST QUARTER OF THE XIX CENTURY

Гуманитарные и юридические исследования, 2021
N the first quarter of the XIX century, the international situation in Europe contributed to the increased interest to the Russian Empire from the audience of European newspapers and magazines.
Vladimir Eremin
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Cultural Haunting and the Trace of the Colonial Other in Arthur Conan Doyle's Short Fiction [PDF]

, 2017
In Home Truths: Fictions of the South Asian Diaspora in Britain (2002), Susheila Nasta argues that “the arrival in Britain of several generations of black and Asian 'immigrants' in the period following decolonization and Independence was not simply the ...
Martín-González, Juan-José
core  

'How compliant do we want to be with the colonoscopy surveillance guidelines?'

, 2007
Objective: To assess the referral practice for surveillance colonoscopy amongst clinicians and to measure whether practice was inline with the current Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of ...
Basnyat, P.S., Chivers, K.C., Taffinder, N.   +2 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

State-of-the-art in studies of glacial isostatic adjustment for the British Isles: a literature review [PDF]

, 2016
Understanding the effects of glacial isostatic adjustment (GIA) of the British Isles is essential for the assessment of past and future sea-level trends.
Alistair Rennie, Arıkan, Bekaert, Bingley, Bähr, Davenport, Elizabeth J Petrie, Firth, Firth, Firth, Jardine, Jim Hansom, Julia Stockamp, Kaneko, Lambeck, Li, Li, Paul Bishop, Peltier, Plag, Ringrose, Samsonov, Shennan, Shennan, Shennan, Shennan, Sissons, Sissons, Sissons, Smith, Smith, Smith, Tong, Van de Plassche, Wang, Woodroffe, Zhenhong Li   +36 more
core   +1 more source

Applying the anisotropy of magnetic susceptibility technique to the study of the tectonic evolution of the West Spitsbergen Fold-and-Thrust Belt

Polar Research, 2016
We demonstrate the use of the anisotropy of magnetic susceptibility (AMS) method to determine the orientation of the principal tectonic strain directions developed during the formation of the West Spitsbergen Fold-and-Thrust Belt (WSFTB).
Katarzyna Dudzisz, Rafał Szaniawski, Krzysztof Michalski, Geoffrey Manby   +3 more
doaj   +1 more source