Results 101 to 110 of about 2,947,430 (350)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Job and the Bible’s Theo-Political Divide

open access: yesReligions, 2019
The book of Job presents a unique and detailed contrastive study of two fundamental and fundamentally opposed religious personae: Job, on the one hand, and the collective image of his friends on the other.
Menachem Fisch
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Transfer of Labour Time on the World Market: Religious Sanctions and Economic Results

open access: yesReligions, 2012
This paper investigates the extent to which a term like “globalization”, especially in its sense of implying the existence of a system, or of dominant features favouring development towards some system, is adaptable to a theory of a world economy which ...
Jørgen Sandemose
doaj   +1 more source

The 'Society of Spectacle' Concept and its Conceptual Correlates [PDF]

open access: yes, 2005
This dissertation aims to show the philosophical content of the ‘society of spectacle’ concept, which was elaborated by a French thinker from the second part of the 20th century, Guy Debord.
Kulyk, Oleksandr
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Professor James Cameron: introduction by a late-coming beneficiary [PDF]

open access: yes, 2014
Mark Elliot’s introduction to this selection of papers from the symposium presents a sketch of James Cameron’s contribution to scholarship as encountered through some of his notable writings. The result is a fascinating tour of Scottish church history in
Elliot, Mark W.
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

1. An Introduction to the Enlightenment

open access: yes, 1958
The word Enlightenment is used to indicate the eighteenth century in the history of ideas of the Western World. It is a word that indicates a sum of ideas about the character of man, his beliefs and activities, and the universe.
Bloom, Robert L.   +6 more
core  

Five minutes with Mark Blyth: “Turn it into things people can understand, let go of the academese, and people will engage” [PDF]

open access: yes, 2012
Mark Blyth became the accidental star of the political blogosphere last year when he appeared in a video promoting the key message behind his upcoming book ‘Austerity: The History of a Dangerous Idea’.
Blyth, Mark
core  

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