Results 51 to 60 of about 178,354,408 (309)

Irony and Perspective-Taking in Children: The Roles of Norm Violations and Tone of Voice

Frontiers in Psychology, 2021
In order to understand most, if not any communicative act, the listener needs to make inferences about what the speaker intends to convey. This perspective-taking process is especially challenging in the case of nonliteral uses of language such as verbal
Franziska Köder, Franziska Köder, Ingrid Lossius Falkum, Ingrid Lossius Falkum   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effective Deoccupation: Towards Responsible Guardianship of Nature

Political Philosophy
The doctrine of effective occupation was developed by colonial powers to justify their sovereignty over newly annexed territories and was measured by animus occupandi, the will to be sovereign; and corpus occupandi, the exercise of sovereignty, both ...
Alejandra Mancilla
doaj   +2 more sources

Human Social Evolution: Self-Domestication or Self-Control?

Frontiers in Psychology, 2020
The self-domestication hypothesis suggests that, like mammalian domesticates, humans have gone through a process of selection against aggression – a process that in the case of humans was self-induced.
Dor Shilton, Mati Breski, Daniel Dor, Eva Jablonka, Eva Jablonka   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The concept of transition in transition. Comparing the postcommunist use of the concept of transition with that found in Soviet ideology

Baltic Worlds, 2014
The postcommunist concept of transition, as it was in use during the 1990s and early 2000s, is analyzed from the viewpoint of its intellectual prehistory.
Kristian Petrov
doaj  

Introduction: Cultures of Disaster

Culture Unbound: Journal of Current Cultural Research, 2015
No abstract available.
Anders Ekström, Kyrre Kverndokk
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source