Results 81 to 90 of about 2,947,430 (350)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2000 A ‘late developer’ argument, common to Psychology and Economic History, can be used to explain cultural innovation. It argues that the 19th century theory of natural selection arose in England and not Germany because of – and not in spite of – England’s ...
Finkelstein, Gabriel
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The normative and epistemological status of pain experiences in modern health care
Tidsskrift for Forskning i Sygdom og Samfund, 2010 This article explores the concept of ‘pain’ and the relation between abstract, detached knowledge and patient experiences and ‘first person perspectives’.
Keld Thorgaard
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Lennart Nilsson’s A Child Is Born: The Many Lives of a Best-Selling Pregnancy Advice Book
Culture Unbound: Journal of Current Cultural Research, 2015 This article examines the circulations and transformations of photographer Lennart Nilsson’s pregnancy advice book Ett barn blir till (A Child Is Born) through its five Swedish editions from 1965 to 2009 as well as some of the translations in English and
Solveig Jülich
doaj
Bankruptcy Procedures for Sovereigns: A History of Ideas, 1976-2001 [PDF]
This paper describes the evolution of ideas to apply bankruptcy reorganization principles to sovereign debt crises. Our focus is on policy proposals between the late 1970s and Anne Krueger's (2001) proposed 'Sovereign Debt Restructuring Mechanism," with ...
Jeromin Zettelmeyer, Kenneth Rogoff
core
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Complexity, parallel computation and statistical physics
, 2005 The intuition that a long history is required for the emergence of complexity in natural systems is formalized using the notion of depth. The depth of a system is defined in terms of the number of parallel computational steps needed to simulate it. Depth
Machta, J.
core +2 more sources