Results 91 to 100 of about 1,742,386 (312)

Analysis of the Discourse in Imam Hussein's Letters to the Kufans During the Ashura Event [PDF]

open access: yesپژوهش های تاریخی
The event of Ashura, occurring in the latter half of the first century AH, gave rise to a religious discourse and ideological framework that, while unequivocally denouncing the oppressive ruler, delineated the roles and attributes of the Imam as the ...
Soodabeh Zajkani, Hedieh Taghavi
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

A performance of reality: handwriting and paper in digital literature [PDF]

open access: yes, 2011
Digital literature emphasizes its own medium, and it brings to the foreground the graphic, material aspects of language. Experiments with the new medium and with the form of language are generally presented and interpreted within a framework of the ...
van Dijk, Y.
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Literature in dialect: the great absentee

open access: yes, 2019
Prose production in dialect is probably the big absentee in Arabic literature textbooks. While poetry in dialect has managed to carve its own small, space in the manuals of history of Arabic literature, the same does not go for novels or short stories ...
F. De Angelis
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Юбилей Е. А. Цыпанова [J. A. Cypanov 60] [PDF]

open access: yesLinguistica Uralica, 2021
Galina Punegova, Aleksej Musanov
doaj   +1 more source

History, Literature, Critical Theory

open access: yes
In this book, Dominick LaCapra continues his exploration of the complex relations between history and literature, considering history as both process and representation.Intro -- History, Literature, Critical Theory -- Contents -- Introduction -- 1.
LaCapra, Dominick.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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