Results 101 to 110 of about 5,286,137 (305)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dialectological base of the machine fund of the bashkir language as a tool for research bashkir dialect continuum

open access: yesOriental Studies, 2018
This article deals with the problem of development of the dialectological base of the Machine fund of the Bashkir language. Along with the written monuments, folklore material, dialect is one of the most important sources for the study of the historical ...
Z. A. Sirazitdinov   +2 more
doaj   +1 more source

A Folk Tale of a Butterfly [PDF]

open access: yes, 2009
This folk tale describes how a butterfly and worm respect one anotherThis collection of 77 audio files focuses on weddings and weddings speeches but also contains: folk tales, folk songs, riddles, tongue twisters, and local history from Bang smad Village
Bkra shis bzang po
core  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Sex Offender Treatment Program: Initial Recidivism Study [PDF]

open access: yes, 1996
This report presents results of a recidivism study of participants in the Sex Offender Treatment Program at Hiland Mountain Correctional Center, Alaska Department of Corrections, from January 1987 to August 1995.
Atrops, Martin E.   +3 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Interview with scholar, translator and lexicographer Donald Rayfield [PDF]

open access: yes, 2015
Donald Rayfield is Emeritus Professor of Russian and Georgian at Queen Mary, University of London. He has been at the forefront of Georgian studies for many years and has published widely on Georgia, authoring several major studies on its literature ...
Karetnyk, B, Rayfield, D
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Exploring Push-Pull Factors Affecting Iranian Jews’ Emigration to Palestine, 1925-1954: A Social History Approach

open access: yesAl-Jami'ah: Journal of Islamic Studies
One of the controversial issues in the twentieth century was the mass immigration of Jews around the world to Palestine/Israel. For the majority of Jews who immigrated from Europe to Palestine/Israel, immigration represented an ideological paradigm ...
Javad Mousavi Dalini, Arash Yousefi
doaj   +1 more source

Home - About - Disclaimer - Privacy