Results 121 to 130 of about 5,585,577 (379)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Al-Jami'ah: Journal of Islamic StudiesOne of the controversial issues in the twentieth century was the mass immigration of Jews around the world to Palestine/Israel. For the majority of Jews who immigrated from Europe to Palestine/Israel, immigration represented an ideological paradigm ...
Javad Mousavi Dalini, Arash Yousefi
doaj +1 more source
The Signaling Role of Promotions: Further Theory and Empirical Evidence [PDF]
, 2006 [Excerpt] An extensive theoretical literature has developed that investigates the role of promotions as a signal of worker ability. There have been no tests, however, of the empirical validity of this idea. In this paper we develop the theory in a manner
Jed Devaro +3 more
core +4 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Journal of Research on History of Medicine, 2018 Malaria is a dangerous disease that was considered one of the leading causes of mortality in Iran up to Pahlavi II period. The small and weak population of Iran could not enjoy favorable economic conditions because of the disease. Therefore, overcoming
Shahnaz Xajeh +2 more
doaj
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
GIANT CYSTIC HYGROMA COLLI IN AN ADULT- A RARE CASE REPORT [PDF]
, 2012 Cystic hygroma (lymphangioma) is often a benign congenital malformation of the lymphatic system that occurs as a result of sequestration or obstruction of lymphatic vessels. Theselesions are usually discovered in infant or children younger than two years
Karunakaran, Anupama +1 more
core +1 more source
History, Literature, and the Writing of the Canadian Prairies (review) [PDF]
, 2007 Lisa Grekul
openalex +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source