Results 211 to 220 of about 6,382,615 (401)

Analysis of classical and quantum mechanical concepts of probability: A synopsis [PDF]

open access: yesarXiv
This paper addresses the central question of what a coherent concept of probability might look like that would do justice to both classical probability theory, axiomatized by Kolmogorov, and quantum theory. At a time when quanta are receiving increased and expanded attention -- think, for example, of the advances in quantum computers or the promises ...
arxiv  

A Complete Transformation of Medicine: John Letterman’s Ambulance Corps

open access: yes, 2019
Looking back on the practices of Civil War Americans, many people tend to believe the Civil War was a particularly dark time in medical history, a time when doctors sawed off limbs to solve any problems and often did it with dirty instruments and no ...
Labbe, Savannah
core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

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