Results 61 to 70 of about 2,002,522 (257)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
S&F_scienzaefilosofia.it, 2015 We will analyze a segment of the very complex theoretical background concerning the current History of Medicine. In this sense, it is indispensable to examine the social contextualization of medicine, its links to political and cultural history, i.e.
Amodio, Paolo
doaj
From postcard to book cover: illustrating connections between medical history and digital humanities
Journal of the Medical Library Association, 2019 This article illustrates the value and impact of collaboration among scholars, archivists, and librarians working across universities and government institutions, and how changes in medium—from a born-physical photograph and printed postcard to a digital
E. Thomas Ewing +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Doctor Nurys Diéguez Andrés (1951-2016), mainstay of the Intensive Care Medicine in Las Tunas
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016 Doctor Nurys Nirma Diéguez Andrés is one of the outstanding personalities in the barely four decades of universal and free medicine in the Cuban province of Las Tunas. She started her graduate studies on Internal Medicine at Dr.
Orlando Rafael Serrano Barrera
doaj
The Middle Ages Contributions to Cardiovascular Medicine
Brazilian Journal of Cardiovascular SurgeryThe historical period called the Middle Ages, a long interval between the 5th and the 15th centuries, is still commonly known as the Dark Ages, especially in the area of health sciences.
André Silva Ranhel +1 more
doaj +1 more source
History matters...through partnerships that advance research, education, and public service
Journal of the Medical Library Association, 2017 The article deals with the ongoing strategic partnership between the History of Medicine Division at the National Library of Medicine and Virginia Polytechnic Institute and State University (Virginia Tech) to allow researchers, educators, and students ...
Jeffrey S. Reznick, E. Thomas Ewing
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source