Results 71 to 80 of about 2,002,522 (257)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Making Medical History Relevant to Medical Students: The First Fifty Years of the Calgary History of Medicine Program and History of Medicine Days Conferences. [PDF]
J Hist Med Allied Sci, 2023 Stahnisch FW.
europepmc +1 more source
THE HISTORY OF MEDICINE IN CANADA [PDF]
Medical History, 1968 A paper read at the Symposium on the History of Medicine in the Commonwealth, organized by the Faculty of the History of Medicine and Pharmacy, and held at the Royal College of Physicians of London on 23 September 1966.
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
History of medicine in medical education: new Italian pathways. [PDF]
J Med Libr Assoc, 2023 Iorio S, Gazzaniga V, Lippi D.
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Polyarchion (πολυάρχιον) in the medicine of Antiquity and Byzantium [PDF]
Farmacja PolskaThe present research is devoted to the history of a medicine used in the Ancient and Byzantine Mediterranean, known in the local medical tradition as polyarchion (πολυάρχιον).
Maciej Kokoszko +3 more
doaj +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Clinical Applications of the History of Medicine in Muslim-Majority Nations. [PDF]
J Hist Med Allied Sci, 2023 Weber AS.
europepmc +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source