Results 51 to 60 of about 2,342 (310)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Philosophy of War and Peace [PDF]
Философия и космология, 2016 In the paper the author comprehends ontology of the war and peace. Using the results of empirical and theoretical research in the field of geophilosophy, as well as neuroscience, psychology, social philosophy and military history, the author comprehends ...
Oleg Bazaluk, Tamara Blazhevych
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2019 What makes human beings, and their way of thinking, unique in the biosphere of the earth is not just the biological-genetic evolution of human cognitive capacities, but also the interaction in historical time with the environment, the socio-cultural ...
Sonesson, Göran, Göran Sonesson
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The Phenomenon of Plica Polonica in Lithuania: A Clash of Religious and Scientific Mentalities
, 2013 This article focuses on the phenomenon of plica polonica, or Polish plait, known in the baroque and Enlightenment periods in the Polish-Lithuanian Commonwealth.
Vaiva Klajumaitė, Klajumaitė, Vaiva
core +1 more source
Autonomy of the family in the modern world
Horyzonty Wychowania, 2017 RESEARCH OBJECTIVE: The purpose of this article is to understand autonomy of the family in the ‘modern’ world by locating the family in the historical changes that led to its present form.
Nidhi Gulati
doaj
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Towards a New—and Broader—History of Hungary’s Troubled Peacemaking
, 2023 This research report presents the endeavors and findings of the Trianon 100 Research Group, which was founded with the support of the Lendület [Momentum] program of the Hungarian Academy of Sciences. Based on a survey of over a dozen volumes published by
Romsics, Gergely +4 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source