Results 71 to 80 of about 879 (266)

HISTORY OF SCIENCE: PROBLEMS AND PRACTICES. HISTORY OF SCIENCE(S), HISTORY OF MENTALITIES, MICRO-HISTORY [PDF]

open access: yesNuncius, 1983
L'article est le point de vue d'un historien de la science, Jacques Roger, a propos du statut institutionnel de l'histoire des sciences. Il affirme la necessite de donner une dimension nouvelle aux revolutions scientifiques en faveur d'une consideration plus attentive des decouvertes ponctuelles qui modifient localement une discipline scientifique.
openaire   +2 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Urbanizace, industrializace, feminismus a ženské řeholní kongregace moderní doby: Několik poznámek k možnostem sociálních dějin k dalšímu výzkumu

open access: yesHistorická sociologie
The study deals with the typically modern phenomenon of European social and church history, which represents the origin and development of women’s religious congregations.
Tomáš Petráček
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

La muerte ante la batalla: Actitudes religiosas y mentalidades colectivas en Almansa a principios del siglo XVIII

open access: yesCuadernos de Historia de España
Durante la Edad Moderna, "guerra" y "muerte" fueron dos términos que estuvieron muy presentes en la sociedad europea. El comienzo del siglo XVIII en España vino marcado por la Guerra de Sucesión, trasformada por sus participantes en un conflicto ...
Ramón Cózar Gutiérrez   +1 more
doaj  

Denkbilder des kulturellen Gedächtnisses Tschechische Lesebuchtexte aus Remarques Im Westen nichts Neues // Denkbilder of Cultural Memory: Remarque’s All Quiet on the Western Front as Anthologized in Czech School Textbooks [PDF]

open access: yesSlovo a Smysl, 2015
This article presents a research project on the history of mentalities in Czech culture of the 20th and the beginning of the 21st century. The project analyses textbooks for the teaching of Czech literature for secondary schools.
Ursula Stohler
doaj  

Colonization and decolonization of global health: which way forward? [PDF]

open access: yesGlob Health Action, 2023
Hussain M   +4 more
europepmc   +1 more source

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