Results 91 to 100 of about 78,143 (301)

Facilitating Expedited Drug Approval—the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, EarlyView.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

“The Teaching of History in a Divided Community”

, 1998
A report of a Council of Europe International Seminar on the theme of “The Teaching of History in a Divided Community”held in Northern Ireland in ...
McCully, Alan
core   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Phylogeographic and Genomic Insights Unveil the Evolutionary History and Post‐Glacial Recolonization Routes of the Palmate Newt (Lissotriton helveticus) Into Europe

Ecology and Evolution
Quaternary glacial cycles have been key drivers of diversification for Holarctic species, promoting divergence, isolation, and extinction processes in numerous taxa.
Bernat Burriel‐Carranza, Jhulyana López‐Caro, Adrià Jordà, Loukia Spilani, Adrián Talavera, Gabriel Mochales‐Riaño, Martiño Cabana, Albert Montori, Pierre‐André Crochet, Ernesto Recuero, Mario García‐París, Íñigo Martínez‐Solano, Daniel Fernandez‐Guiberteau, Salvador Carranza   +13 more
doaj   +1 more source

Dispersal and life-history traits in a spider with rapid range expansion

Movement Ecology, 2020
Background Dispersal and reproduction are key life-history traits that jointly determine species’ potential to expand their distribution, for instance in light of ongoing climate change.
Marina Wolz, Michael Klockmann, Torben Schmitz, Stano Pekár, Dries Bonte, Gabriele Uhl   +5 more
doaj   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Asylum Seekers and Security at the Northern Finnish-Russian Border: Analysing ‘Arctic Route Episode’ of 2015-2016

RUDN Journal of Economics, 2017
Europe experienced an unprecedented peak in asylum seekers in 2015. Over a million asylum seekers entered the European Union across the Mediterranean Sea and travelled by all means of transport, including by foot, from South to Central and Northern parts
Minna Piipponen, Joni Virkkunen
doaj   +1 more source

The Cult of Saints and Legitimization of Elite Power in East Central and Northern Europe up to 1300

While Northern and East Central Europe are often considered to have been peripheral parts of medieval Latin Christendom, they nevertheless embraced many of the same cultural impulses found in more central areas.

core   +1 more source

Bidirectional Photoswitching of a Tailored Azobenzene with Red and Far‐Red Light Involving Triplet Sensitization in an Aqueous System

Advanced Science, EarlyView.
The action spectrum of a tailored azobenzene is shifted toward bio‐optical window through the chemical modification of its singlet and triplet energy levels. Consequently, the bidirectional photo‐switching of azobenzene in physiological conditions is achieved when excited by red and far‐red light, which offers greater tissue penetration.
Mila Miroshnichenko, Helen Hölzel, Edvinas Orentas, Karolis Kazlauskas, Pedro Ferreira, Fabienne Dumoulin, Carles Alcaide, Miquel Solà, Roger Bresolí‐Obach, Santi Nonell, Pankaj Bharmoria, Kasper Moth‐Poulsen   +11 more
wiley   +1 more source