Results 51 to 60 of about 167,672,586 (309)

The Effectiveness of Modified Mediterranean and Traditional Persian Diets in Fatigue and Depressive Severity in People with Multiple Sclerosis: A Randomized Controlled Clinical Trial [PDF]

Iranian Journal of Medical Sciences
Background: Research into managing depression and fatigue, two typical symptoms of multiple sclerosis (MS), is constantly expanding. This study aimed to assess the efficacy of the modified Mediterranean (MED) diet or the Traditional Persian (TP) diet in ...
Mohammad Hossein Sharifi, Maryam Poursadeghfard, Maryam Afshari, Zahra Alizadeh, Mohammad Vatanpour, Mitra Soltani, Hossein Molavi Vardanjani, Amir Mohammad Jaladat, Majid Nimrouzi   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Os Arquivos Brasileiros de Nutrição: uma revisão sobre produção científica em nutrição no Brasil (1944 a 1968)

Cadernos de Saúde Pública
Este trabalho consiste em uma revisão de 209 artigos originais publicados pelos Arquivos Brasileiros de Nutrição (1944/1968), um periódico editado pelo médico-nutrólogo Josué de Castro, diretor-fundador do Instituto de Nutrição da Universidade do Brasil (
Francisco de Assis Guedes de Vasconcelos
doaj   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ethics and nutrition safety in patient care during COVID-19 pandemic [PDF]

, 2020
The coronavirus disease 2019 (COVID-19) pandemic has impacted all aspects of our population. Ethical dilemmas related to the care of patients in the COVID-19 pandemic need to be rapidly addressed by multidisciplinary bioethics committees, with the ...
Permatasari, Dian
core   +1 more source

Enteral Nutrition in Crohn’s Disease: An Underused Therapy

Gastroenterology Research and Practice, 2013
This paper reviews the literature on the history, efficacy, and putative mechanism of action of enteral nutrition for inflammatory bowel disease in both paediatric and adult patients.
S. Kansal, J. Wagner, C. D. Kirkwood, A. G. Catto-Smith   +3 more
doaj   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

75-Year History of the Minnesota Nutrition Conference [PDF]

, 2014
Linn, Jim; Hansen, Abigail; Martinson, Krishona; Goihl, John. (2014). 75-Year History of the Minnesota Nutrition Conference.
Martinson, Krishona, Linn, Jim, Hansen, Abigail, Goihl, John   +3 more
core