Results 41 to 50 of about 1,002,372 (285)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Richard Kirwan a [united] Irish man of science in Europe

Condensed Matter Physics
The late eighteenth and early nineteenth centuries have long been considered as a formative period for modern Irish political traditions such as nationalism, republicanism and unionism.
R. Folk
doaj   +1 more source

A History of Physics [PDF]

Nature, 1899
IT is a formidable undertaking to write a book on the history of physics beginning with the dawn of science and including helium and Rontgen rays, and the task does not become easier when the whole has to be condensed into the narrow limits of 300 pages.
openaire   +1 more source

Nuclear Astrophysics

, 2005
Nuclear physics has a long and productive history of application to astrophysics which continues today. Advances in the accuracy and breadth of astrophysical data and theory drive the need for better experimental and theoretical understanding of the ...
Brune, Carl R.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Os princípios fundamentais ao longo da história da física

Revista Brasileira de Ensino de Física
Ressaltamos a natureza empírica dos princípios da Física, emfatizando sua independência quanto à sua aplicabilidade, característica que os acompanham ao longo da história da própria Física.
José Plínio Baptista
doaj   +1 more source

Entropy? Exercices de Style

Entropy, 2019
Since its inception, the concept of entropy has been known under a variety of guises and been used in an increasing number of contexts, achieving an almost rock star-like status in both the sciences and popular culture.
Rocco Gaudenzi
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Kosmologia wczoraj i dziś - przeżywanie kawałka historii

Zagadnienia Filozoficzne w Nauce, 2010
Short recollections of an author who with his own eyes witnessed the development of cosmology from purely theoretical speculations to the mature experimental science.
Michał Heller
doaj  

O papel das emulsões nucleares na institucionalização da pesquisa em física experimental no Brasil

Revista Brasileira de Ensino de Física
Neste artigo, descrevemos e analisamos a introdução e o uso da técnica das emulsões nucleares no Brasil. Apesar de pesquisas consistentes na área de raios cósmicos terem sido feitas na década de 1940 neste país, os físicos aqui começaram a empregar a ...
Cássio Leite Vieira, Antonio A.P. Videira   +1 more
doaj   +1 more source