Results 51 to 60 of about 1,002,372 (285)

Nurturing Genius: the Childhood and Youth of Kelvin and Maxwell

open access: yesSubstantia, 2017
William Thomson and James Clerk Maxwell, nineteenth century natural philosophers, were friends and colleagues (Thomson was Maxwell’s senior by seven years).
John Lekner
doaj   +1 more source

Overview of the Tevatron Collider Complex: Goals, Operations and Performance

open access: yes, 2011
For more than two decades the Tevatron proton-antiproton collider was the centerpiece of the world's high energy physics program. The collider was arguably one of the most complex research instruments ever to reach the operation stage and is widely ...
C.W. Schmidt   +10 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A Gravitação Universal: um texto para o Ensino Médio

open access: yesRevista Brasileira de Ensino de Física
Neste trabalho, propomos uma forma alternativa para apresentar o conceito de Gravitação Universal ao aluno do Ensino Médio. A História da Física - por apresentar os problemas que levaram à formulação de um dado conceito - mostra os elementos que dão ...
Penha Maria Cardoso Dias   +2 more
doaj   +1 more source

A Theory of Inertia Based on Mach’s Principle

open access: yesUniverse, 2019
A non-relativistic theory of inertia based on Mach’s principle is presented as has been envisaged, but not achieved, by Ernst Mach in 1872. The central feature is a space-dependent, anisotropic, symmetric inert mass tensor.
Volkmar Putz
doaj   +1 more source

Philosophy of Computer Science: An Introductory Course [PDF]

open access: yes, 2005
There are many branches of philosophy called “the philosophy of X,” where X = disciplines ranging from history to physics. The philosophy of artificial intelligence has a long history, and there are many courses and texts with that title.
Rapaport, William J.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Explorando História da Ciência na Amazônia: O Museu Interativo da Física

open access: yesRevista Brasileira de Ensino de Física
No ano de 2008, professores e alunos da Faculdade de Física da Universidade Federal do Pará realizaram uma iniciativa pioneira para divulgação de História da Ciência na Amazônia brasileira. Esta iniciativa, denominada Museu Interativo da Física, passou a
Jocasta Caldas   +2 more
doaj   +1 more source

A study on the impact of teaching history of physics on the knowledge and attitude of female high school students [PDF]

open access: yesفصلنامه نوآوری‌های آموزشی, 2011
Lots of findings showed that the use of history of science is very influential in providing a proper understanding towards science among students.
Khadijeh Mahboubi   +2 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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