Results 71 to 80 of about 1,002,372 (285)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Dois problemas práticos de eletricidade Vitoriana e sua discussão no ensino secundário e universitário

Revista Brasileira de Ensino de Física
Dois problemas práticos inspirados na biografia de Oliver Heaviside de Paul Nahin, a iluminação residencial e a determinação do ponto de perda de corrente em um cabo telegráfico, são apresentados, discutidos e resolvidos no quadro da eletricidade ...
A.C. Tort
doaj   +1 more source

Cosmoparticle Physics -the Challenge for the Millenium

, 2003
Cosmoparticle physics is the natural result of development of mutual relationship between cosmology and particle physics. Its prospects offer the way to study the theory of everything and the true history of the Universe, based on it, in the proper ...
Khlopov, Maxim Yu.
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A telegrafia eléctrica nas páginas de "O Instituto", revista da Academia de Coimbra

Revista Brasileira de Ensino de Física
Analisamos os avanços da telegrafia eléctrica e da telegrafia sem fios no mundo e, em particular, em Portugal, com base em artigos da revista O Instituto, publicada pelo Instituto de Coimbra, uma sociedade científica, fundada em 1852, que reuniu um vasto
António José F. Leonardo, Décio R. Martins, Carlos Fiolhais   +2 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Demonstração didática da interação entre correntes elétricas

Revista Brasileira de Ensino de Física
Apresentamos a primeira experiência crucial de Ampère mostrando a interação entre dois fios metálicos conduzindo correntes elétricas. Discutimos sua importância na história da física.
M.P. Souza Filho, J.P.M.C. Chaib, J.J. Caluzi, A.K.T. Assis   +3 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Notes on the historical conceptual streams for mathematics and physics teaching

Lietuvos Matematikos Rinkinys, 2013
Based on recent researches of mine concerning history and epistemology of sciences (physics and mathematics) one side and foundations of sciences within my physics and mathematics teaching other side, in this paper I briefly discuss and report the role ...
Raffaele Pisano
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source