Results 91 to 100 of about 5,697,291 (306)

Atoll research bulletin. [PDF]

, 2005
no.531-542 ...
National Museum of Natural History (U.S.), National Research Council (U.S.). Pacific Science Board., Smithsonian Institution., Smithsonian Institution. Press, United States. Bureau of Sport Fisheries and Wildlife.   +4 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A rota dos estudos sobre a cochonilha em Portugal e no Brasil no século XIX: caminhos desencontrados The route of the studies of cochineal in Portugal and Brazil in the nineteenth century: uncrossed paths

Química Nova, 2007
For imparting an intense and long-lasting red to fabrics, cochineal remained in high demand during the eighteenth and nineteenth centuries. This period witnessed, accordingly, several initiatives aimed at producing the precious dye: publication of ...
Márcia Helena Mendes Ferraz
doaj   +1 more source

Wikipedia as a tool for contemporary history of science: A case study on CRISPR. [PDF]

PLoS One, 2023
Benjakob O, Guley O, Sevin JM, Blondel L, Augustoni A, Collet M, Jouveshomme L, Amit R, Linder A, Aviram R.   +9 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

HISTORY OF SCIENCE: PROBLEMS AND PRACTICES. HISTORY OF SCIENCE(S), HISTORY OF MENTALITIES, MICRO-HISTORY [PDF]

Nuncius, 1983
L'article est le point de vue d'un historien de la science, Jacques Roger, a propos du statut institutionnel de l'histoire des sciences. Il affirme la necessite de donner une dimension nouvelle aux revolutions scientifiques en faveur d'une consideration plus attentive des decouvertes ponctuelles qui modifient localement une discipline scientifique.
openaire   +2 more sources

Hume's Natural Philosophy and Philosophy of Physical Science [PDF]

, 2020
This book contextualizes David Hume's philosophy of physical science, exploring both Hume's background in the history of early modern natural philosophy and its subsequent impact on the scientific ...
Slavov, Matias
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

SCIENTISTS IN OLD GDANSK: PREHISTORY AND 16th CENTURY

TASK Quarterly, 2001
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ANDRZEJ JANUSZAJTIS
doaj