Results 31 to 40 of about 1,883,900 (258)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conversion Prediction Using Multi-task Conditional Attention Networks to Support the Creation of Effective Ad Creative

, 2019
Accurately predicting conversions in advertisements is generally a challenging task, because such conversions do not occur frequently. In this paper, we propose a new framework to support creating high-performing ad creatives, including the accurate ...
Bahdanau Dzmitry, Kingma Diederik P, Kudo Taku, Lin Zhouhan, Luong Thang, Thomaidou Stamatina, Xu Kelvin, Yang Hongxia   +7 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Climate and colonialism [PDF]

, 2018
Recent years have seen a growth in scholarship on the intertwined histories of climate, science and European imperialism. Scholarship has focused both on how the material realities of climate shaped colonial enterprises, and on how ideas about climate ...
Adamson G. C. D., Arnold D., Aubin D., Baker A. G., Bankoff G., Barton G. A., Beattie J., Beattie J., Beinart W., Bennett B., Bennett B. M., Bennett B. M., Berland J., Bonneuil C., Brock W. H., Carey M., Carter C. R., Coen D. R., Coen D. R., Culver L., Curtin P. D., Cushman G. T., Cushman G. T., Cushman G. T., Daston L., Davis D. K., Davis M., Douglas K., Drayton R. H., Edmond R., Endfield G., Endfield G. H., Fenby C., Fenby C., Fleming J. R., Fleming J. R., Fleming J. R., Fleming J. R., Gerbi A., Golinski J., Grove R. H., Grove R. H., Hall M. B., Harries P., Harrison M., Hazareesingh S., Heffernan M., Henry M., Holland P., Howell J., Howkins A., Hughes J. D., Hulme M., Hunt B. J., Island of Mauritius Meteorological Service, Jepson W., Johnston K., Kennedy D., Kneale J., Landau P. S., Legg S., Lehmann P. N., Lehmann P. N., Livingstone D. N., Livingstone D. N., Livingstone D. N., Livingstone D. N., Livingstone D. N., Livingstone D. N., Locher F., Létolle R., Lüdecke C., Mahony M., Mahony M., Marcot J.‐L., Marsden B., Mathe‐Shires L., Matson K., McKittrick M., McKittrick M., Meinig D. W., Meinig D. W., Meyer W. B., Miller D. P., Morgan R. A., O'Brien C., O'Brien C., O'Gorman E., Osborne M. A., Pietruska J. L., Powell J. M., Pratt M. L., Prest J., Said E. W., Schwarz E. H. L., Siiskonen H. O., Taylor‐Brown E., Turner R., Udías A., Walker M., Wheeler R., Williamson F., Williamson F., Young R. J. C.   +103 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Évora Studies in the Philosophy and History of Science Volume Two From Ontology To Structure [PDF]

, 2018
The structuralist approaches retake the war, characteristic of ancient Greek thought, between the partisans of matter and the ‘friends of ideas’, although they abandon the metaphysical and ontological issues, thus favouring the methodological aspects of ...
Paz, María de, Príncipe, João
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A history of the histories of econometrics. [PDF]

Understanding the history of econometrics as a modern science also asks for understanding of the development of the image of science, which includes the history of philosophy of science and the history of economic methodology. Beside that philosophers of
Boumans, Marcel, Dupont-Kieffer, Ariane
core   +1 more source