Results 51 to 60 of about 1,889,906 (345)

Ideas in the History of Nano/Miniaturization and (Quantum) Simulators: Feynman, Education and Research Reorientation in Translational Science [PDF]

Proceedings of The 19th International Electronic Conference on Synthetic Organic Chemistry, 2015
Cultural history of nanominiaturization, computing, quantum computing and simulating is necessary to comprehend human character and place it in the whole of living beings. Ideas in the history of physics by Feynman, etc. are valued by the questions that generate.
Francisco Torrens, Gloria Castellano
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Explainable AI (XAI): History, Basic Ideas and Methods

International Journal of Advanced Research in Science, Communication and Technology
Explainable Artificial Intelligence (XAI) is a field that aims to make artificial intelligence (AI) processes more transparent, explainable, and understandable.
Prachi Zodage, Hussain Harianawala, Hafsa Shaikh, Asad Kharodia   +3 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

RUNNING DETAILS ON THE TWO MOVEMENTS IN THE INTELLECTUAL HISTORY OF SCIENCE AND IDEAS [PDF]

Journal of Baltic Science Education, 2016
A long tradition concerning the causes of the planetary movements existed as to the movements on the earth: the so called problem de motu locali. Starting from late middle Ages many criticisms were carried out against the Aristotelian doctrine of natural and violent motions.
openaire   +1 more source

The Logic of Time: from Aristotle to Computer Science [PDF]

, 2017
Charla tipo conferencia-seminario dada para alumnos de un másterThis short course will explore that continuous thread which connects the discussion about time in philosophy with the modern use of temporal logic in computer science. It will go through the
Bresolin, Davide
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Further Developing the Word Rain Text Visualisation Technique in a Digital History Project

Digital Humanities in the Nordic and Baltic Countries Publications
The development of the Word Rain text visualisation technique started as a theoretical project, in which insights from previous NLP and text visualisation research were used for creating a visualisation that addressed some of the problems associated ...
Maria Skeppstedt, Magnus Ahltorp, Gijs Aangenendt, Ylva Söderfeldt   +3 more
doaj   +1 more source

The Formation and Evolution of Massive Black Holes

, 2012
The past 10 years have witnessed a change of perspective in the way astrophysicists think about massive black holes (MBHs), which are now considered to have a major role in the evolution of galaxies.
Fender, Kormendy, M. Volonteri, McConnell, Mortlock   +4 more
core   +2 more sources