Results 61 to 70 of about 1,166 (212)

Science and History of Science: between Comte and Canguilhem

Transversal: International Journal for the Historiography of Science, 2018
In the present article, we discuss the specificity of the object of the history of science as an autonomous and interdisciplinary field of studies by nature and origin, placed at the interface of history, epistemology and science, and focus on some key ...
Márcia H. M. Ferraz, Ana M. Alfonso-Goldfarb, Silvia Waisse   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Curated 'UNESCO Courier' 1.0: Annotated Corpora for Digital Research in the Global Humanities

Journal of Open Humanities Data
The monthly magazine of the United Nations Educational, Scientific and Cultural Organization, founded in 1948 as The UNESCO Courier, represents an extraordinary resource for research on global themes in the humanities. We present the Curated Courier 1.0,
Benjamin G. Martin, Fredrik Mohammedi Norén, Roger Mähler, Andreas Marklund, Oriane Martin   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

UNESCO’s Proceedings, 1945–2017: A Bilingual Digital Text Corpus

Journal of Open Humanities Data
The record of the meetings of UNESCO’s General Conference offers a valuable resource for research in the global humanities. We present a digital text corpus, including metadata and supplementary material, that makes the complete record of these meetings ...
Benjamin G. Martin, Fredrik Mohammedi Norén, Roger Mähler, Andreas Marklund, Oriane Martin   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Niceness or toughness? Gendered norms as regulators of employee communication of risks and problems

Social Sciences and Humanities Open
Various forms of silence counteract the idea of an open organisation. A work environment in which employees express themselves freely about risks and problems, is a prerequisite for a sustainable and safe working environment.
Kristina Hermansson, Erica Nordlander, Lotta Dellve   +2 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source