Results 211 to 220 of about 156,592 (295)

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Interactions between mosquito genetic background and Wolbachia strain affect dengue virus blocking and fitness in South American populations of Aedes aegypti. [PDF]

PLoS Negl Trop Dis
Ser SL, Dennington NL, Engler HI, Harris ML, Jones MJ, Avila FW, Caragata EP, Hoffmann AA, Maciel de Freitas R, McGraw EA.   +9 more
europepmc   +1 more source

Extra Climate Benefits From Afforestation Due to Reduced Forest Fragmentation in China

Advanced Science, EarlyView.
Afforestation in China reduced forest fragmentation in 2015, transforming 51.8 M ha of edge forests into interior forests. This enhanced carbon sequestration (1.4±0.2 Pg CO2e, a cooling biogeochemical effect), while reduced albedo (−0.9 Pg CO2e, a warming biophysical effect) partially offset the gain, yielding a net extra climate benefit of ...
Nan Meng, Wei Li, Philippe Ciais, Martin Brandt, Xiaowei Tong, Yanzheng Yang, Guofeng Shen, Wei Du, Lei Zhu, Yi Leng, Minxuan Sun, Mengjie Han, Xuemei Zhang, Jie Zhang, Nan Wang, Dan Tong, Chao Wu, Wenhao Dong, Shu Tao, Bo Pan   +19 more
wiley   +1 more source

Exploring Non-Pharmacological Interventions as Part of Multimodal Management to Prevent Opioid Misuse in Adults Prescribed Opioids for Chronic Pain. [PDF]

J Clin Med
Alrashid MA, Zumot MS, Fredericks S.
europepmc   +1 more source

History of inclusive physical education in South America

, 2023
Mauerberg-deCastro, Eliane, Campbell, Debra Frances, Heck, S., Block, M. E.   +3 more
openaire   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Chromosome-Level Reference Genome of the Beach False Foxglove, Agalinis fasciculata (Orobanchaceae). [PDF]

Genome Biol Evol
Pezzi PH, Latvis M.
europepmc   +1 more source

High Free‐Volume Imidazole‐Based Ionomers for High‐Temperature Proton Exchange Membrane Fuel Cells

Advanced Science, EarlyView.
High free‐volume imidazole‐based ionomers (PF4IM‐72) enable enhanced phosphoric acid uptake and efficient proton transport, delivering peak power densities of 0.645 W cm−2 at 160 °C and 0.838 W cm−2 at 200 °C in HT‐PEMFCs. This work highlights a promising platform for next‐generation ionomers with improved high‐temperature performance and stability ...
Ge Chao, Hyeon Keun Cho, Chang Yeon Hyun, Shirong Li, Jong Geun Seong, So Young Lee, Nanwen Li, Young Moo Lee   +7 more
wiley   +1 more source

Spatial and temporal uplift history of South America from calibrated drainage analysis

, 2018
Tribaldos, V Rodríguez,; White, NJ,; Roberts, GG,; Hoggard, MJ,
core  

Correction for Craig et al., Lipid residue analysis reveals divergent culinary practices in Japan and Korea at the dawn of intensive agriculture. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source