Results 101 to 110 of about 3,716,054 (304)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Is War Necessary for Economic Growth? Military Procurement and Technology Development [PDF]
New radical general purpose technologies have been the drivers of economic growth in the United States economy in recent economic history. In this paper I review the role of military and defense related research, technology development, and procurement ...
Ruttan, Vernon W.
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Graphical Reconstruction of the Lost Paper Mill at Locks 11–12 of the Canal de Castilla
HeritageNear the 11–12 locks of the Canal de Castilla, there once stood a paper mill built in the 18th century and dismantled in 1983. Despite the scarce physical remains, the absence of original plans, and the limited availability of data, this research aims to
José M Geijo-Barrientos +3 more
doaj +1 more source
The design of licensing contracts: Chemicals, Pharmaceuticals, and Electrical Engineering in Imperial Germany [PDF]
We investigate a sample of 180 technology licensing contracts closed by German chemical, pharmaceutical, and electrical engineering companies between 1880 and 1913.
Carsten Burhop, Thorsten Lübbers
core
Shifting Agendas and Competing Interests within Public Health, Science and Technology, and Medicine in Africa [PDF]
, 2018 In lieu of the abstract, here is the review\u27s first paragraph: Until recent times, the conventional history of public health, of science and technology, and of medicine has been presented in the West as a tale of out-migration from the advanced ...
Baronov, David
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Surveillance, integrity and metadata in the information age
LychnosIn August 1994, the Prime Minister of Sweden, Carl Bildt, publicly announced the formation of The Information and Communication Technology Commission.
Peter Bennesved
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Philosophy of Blockchain Technology - Ontologies [PDF]
, 2019 About the necessity and usefulness of developing a philosophy specific to the blockchain technology, emphasizing on the ontological aspects. After an Introduction that highlights the main philosophical directions for this emerging technology, in ...
Sfetcu, Nicolae
core +1 more source