Results 51 to 60 of about 921,158 (313)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Tunisian engineers: protagonists of Tunisia’s modernisation. Two key moments: 1956 and 1987

Acta Polytechnica
Engineers have played a key role in Tunisia’s modernisation process during and after its independence. They were crucial in almost all aspects of life. From the beginning of the reformist project, they were close to power and even made demands according
Amani Mansouri, Jorge Alonso Rodríguez Ortiz   +1 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Making the History of Computing. The History of Computing in the History of Technology and the History of Mathematics [PDF]

Revue de Synthèse, 2018
Abstract A history of writing the history of computing is presented in its relationship to the history of mathematics. As with many historiographies, the initial history of computing was very much an internalistic history. In the late 1970s, the field became more serious and started looking at the histories of mathematics and technology for ...
de Mol, Liesbeth, Bullynck, Maarten
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Osmanlı Devleti’nde İletişim Araçlarının Kontrolü: “Telefon Tevkifleri”

Osmanli Bilimi Arastirmalari, 2020
On dokuzuncu yüzyılın bilim ve teknik alanındaki başlıca icatlarından biri telefondur. 1875’teki icadından sonra dünya ülkelerine hızla yayılmıştır. Osmanlılar, patenti Alexander Graham Bell tarafından 1876’de alınan telefon ile II. Abdülhamid döneminde,
Şeyhmus Bi̇ngül
doaj  

Self-Writing Machines: Technology and the Question of the Self

communication +1, 2015
In order to show that technology mediates between man and machine, I will discuss in this text a literally other or alter-knowledge system that also heavily relied on self-writing machines: spiritualism.
Christian Kassung
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Catalog of Lamar State College of Technology School of Vocations

, 1966
Catalog of courses offered by the Lamar State College of Technology School of Vocations for the year 1967-1968, as well as general information about the university, programs, and policies.
Lamar State College of Technology. Lamar School of Vocations.
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source