Results 51 to 60 of about 3,716,054 (304)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Message is the Medium: Electronically Helping Writing Tutors Help Electronically [PDF]

open access: yes, 2013
The history of online writing centers is a history of doubt. I experienced those reservations in 2009, when, in addition to traditional face-to-face peer tutoring, I launched my own online peer tutoring program and began training undergraduates to ...
Kavadlo, Jesse
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Prague postal time service: clock and sirens – improbable connection

open access: yesActa Polytechnica
The goal of this paper is to present the origin, development, and technical parameters of the Postal Time Service, which was established in the capital of Czechoslovakia – Prague, gradually in the years 1933–1935.
Martin Dominik Hrtus
doaj   +1 more source

The History of Science in Latin America in its own terms

open access: yesRevista Portuguesa de História, 2020
This article conducts a comparative analysis of two journals: Quipu, created in 1984 by the Latin American Society for the History of Sciences and Technology in Mexico, published until 1994 and shortly relived between 1999 and 2000, and the Brazilian ...
Marcia Regina Barros da Silva
doaj   +1 more source

History Begins in the Future: On Historical Sensibility in the Age of Technology [PDF]

open access: yes, 2018
The humanities and the social sciences have been hostile to future visions in the postwar period. The most famous victim of their hostility was the enterprise of classical philosophy of history, condemned to illegitimacy precisely because of its ...
Simon, Zoltán Boldizsár
core  

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

open access: yes
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana   +8 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tunisian engineers: protagonists of Tunisia’s modernisation. Two key moments: 1956 and 1987

open access: yesActa Polytechnica
Engineers have played a key role in Tunisia’s modernisation process during and after its independence. They were crucial in almost all aspects of life. From the beginning of the reformist project, they were close to power and even made demands according
Amani Mansouri   +1 more
doaj   +1 more source

Teacher change in a developing curriculum area: the example of trade teachers in the New Zealand technology curriculum [PDF]

open access: yes, 2000
Technology education for all students is a relatively new phenomenon in national and international curricula. Although New Zealand has a long history of technical education in the senior primary and secondary school, a curriculum for technology education
Ewington, Louis, Jones, Alister
core   +1 more source

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