Results 61 to 70 of about 3,716,054 (304)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Osmanlı Devleti’nde İletişim Araçlarının Kontrolü: “Telefon Tevkifleri”
Osmanli Bilimi Arastirmalari, 2020 On dokuzuncu yüzyılın bilim ve teknik alanındaki başlıca icatlarından biri telefondur. 1875’teki icadından sonra dünya ülkelerine hızla yayılmıştır. Osmanlılar, patenti Alexander Graham Bell tarafından 1876’de alınan telefon ile II. Abdülhamid döneminde,
Şeyhmus Bi̇ngül
doaj
Self-Writing Machines: Technology and the Question of the Self
communication +1, 2015 In order to show that technology mediates between man and machine, I will discuss in this text a literally other or alter-knowledge system that also heavily relied on self-writing machines: spiritualism.
Christian Kassung
doaj +1 more source
, 2018 An opinion often cited among educational technology (edtech) professionals is that theirs is a fast-changing field. This statement is sometimes used as a motivation (or veiled threat) to senior managers to embrace edtech because if they miss out now, it ...
Weller, Martin
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Science, technology and society for our century [inaugural lecture, 16 April 2013] [PDF]
, 2013 The links between science and technology, on the one hand, and wider society, on the other, have been the focus of growing attention over the past two generations.
Johnston, S.F.
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source