Results 121 to 130 of about 927,236 (300)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Expert Discussion on Taking a Spiritual History

open access: yes, 2017
This article elaborates on the hazards of spiritual history taking. It provides expert insights to consider before entering the field. In summer 2012, a group of spiritual care experts were invited to discuss the complexity of taking spiritual histories
Eckhard Frick   +3 more
core   +1 more source

Development of Clinical Reasoning and History-Taking Remediation Training

open access: yesJournal of Medical Education and Family Medicine
Objective: Clinical reasoning and history skills are essential for health care professionals. The design of "remediation" training to compensate for "learning gaps", which may occur for various reasons in educational programs, is recommended.
Mukadder İnci Başer Kolcu   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Women in Policing: A History Through Personal Stories

open access: yes
The history of policing in Britain is a considerably under-researched subject, and the advancement of women within that history even more so. This book seeks to fill that gap, by tracking the progress of women in policing – a story that is longer and ...

core  

Impact of a Comprehensive Sexual Health History Taking Tool

open access: yes, 2020
: Obtaining a comprehensive sexual health history is an important part of the patient history taking process and is essential to providing high-quality, patient-centered, and accessible healthcare.

core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Dual Coaching of Medical Clerkship Students’ History Taking Skills by Volunteer Inpatients at the Bedside and Faculty Physicians on Zoom During the COVID-19 Pandemic

open access: yes
Kush S Patel,1 Ronald J Anderson,1,* Carolyn B Becker,1,* William C Taylor,1,* Anne F Liu,1,* Anubodh S Varshney,2,* Nadaa B Ali,1,* Barbara J Nath,3,* Stephen R Pelletier,4 Helen M Shields,1 Nora Y Osman1 1Department of ...
Liu AF   +10 more
core  

“YOUNG HISTORIANS WRITE HISTORY of ÜSKÜDAR, TAKING DOCUMENTARY”: A SUMMARY of a LOCAL and ORAL HISTORY PROJECT

open access: yes, 2018
Son on yılda Sosyal Bilgiler ve Tarih derslerinin öğretiminde yerel tarih, sözlü tarih, tarihsel empati, kanıt temelli tarih öğretimi gibi alana has öğretim yöntemleri de ön plana çıkmaya başlamıştır. Ulusal tarihin ötesinde, yerel tarih bir şehrin ya da

core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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