Results 81 to 90 of about 387 (168)

PyamilySeq: exposing the fragility of conventional gene (re)clustering and prokaryotic pangenomic inference methods. [PDF]

NAR Genom Bioinform
Dimonaco NJ.
europepmc   +1 more source

Functional Differences in Muscle Architecture Across the Pelvis and Hind Limb of Primates

American Journal of Biological Anthropology, Volume 190, Issue 4, August 2026.
ABSTRACT Objectives Understanding the architectural diversity of primate musculature is essential for interpreting locomotor function and reconstructing evolutionary adaptations. This study examines whether interspecific differences in pelvic and hind limb muscle architecture reflect functional differentiation among major muscle groups.
Emma Guimaraes, Evie Vereecke, Ashleigh L. Wiseman   +2 more
wiley   +1 more source

Large Library Docking for Polypharmacology. [PDF]

J Med Chem
Wu Y, Vigneron S, Braz J, Srinivasan K, Fink EA, Huang XP, Xu X, Huebner H, Kim JY, Wang J, Pfeiffer T, Sakamoto K, Radchenko DS, Rodriguiz RM, Moroz YS, Irwin JJ, Gmeiner P, Billesboelle C, Roth BL, Basbaum AI, Manglik A, Wetsel WC, Shoichet BK.   +22 more
europepmc   +1 more source

New craniodental materials of Falcarius utahensis (Theropoda: Therizinosauria) reveal patterns of intraspecific variation and cranial evolution in early coelurosaurians

The Anatomical Record, Volume 309, Issue 8, Page 1995-2048, August 2026.
Abstract Despite documented ecomorphological shifts toward an herbivorous diet in several coelurosaurian lineages, the evolutionary tempo and mode of these changes remain poorly understood, hampered by sparse cranial materials for early representatives of major clades. This is particularly true for Therizinosauria, with representative crania best known
William J. Freimuth, Lindsay E. Zanno
wiley   +1 more source

Water-Based Pharmacophore Modeling in Kinase Inhibitor Design: A Case Study on Fyn and Lyn Protein Kinases. [PDF]

J Chem Inf Model
Ljubič M, Sollner Dolenc M, Borišek J, Perdih A.   +3 more
europepmc   +1 more source

Applications of Artificial Intelligence in Cancer Diagnosis and Treatment

Cancer Medicine, Volume 15, Issue 8, August 2026.
This review explores how AI and multimodal data fusion transform oncology through enhanced screening, precision diagnosis, and personalized therapy. By dissecting core challenges—including data bias and explainability—it provides a strategic framework for the digital transformation and ethical implementation of AI in clinical cancer care.
Yifeng Xie, Zixuan Wang, Zhiwen Zeng, Tongyao Xin, Shaofei Yuan, Feiwei Qin, Zhonglin Chen   +6 more
wiley   +1 more source

The impact of library size and scale of testing on virtual screening. [PDF]

Nat Chem Biol
Liu F, Mailhot O, Glenn IS, Vigneron SF, Bassim V, Xu X, Fonseca-Valencia K, Smith MS, Radchenko DS, Fraser JS, Moroz YS, Irwin JJ, Shoichet BK.   +12 more
europepmc   +1 more source

Polygenic adaptation from standing genetic variation allows rapid ecotype formation. [PDF]

Elife, 2023
Fuhrmann N, Prakash C, Kaiser TS.
europepmc   +1 more source

Interferon‐induced transmembrane (IFITM) proteins at the tumour–immune interface: A four‐axis framework for their context‐dependent roles

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Interferon‐induced transmembrane (IFITM) function in cancer is set by four contextual coordinates, not by family membership. Acute interferon input drives major histocompatibility complex class I (MHC‐I)‐linked immunogenicity; chronic input drives programmed death‐ligand 1 (PD‐L1)‐coupled resistance.
Zhe Liu, Jie Meng, Zengyan Lai, Fuqiu Li, Sha Lv   +4 more
wiley   +1 more source

Knot or not? Identifying unknotted proteins in knotted families with sequence-based Machine Learning model. [PDF]

Protein Sci
Sikora M, Klimentova E, Uchal D, Sramkova D, Perlinska AP, Nguyen ML, Korpacz M, Malinowska R, Nowakowski S, Rubach P, Simecek P, Sulkowska JI.   +11 more
europepmc   +1 more source