Results 261 to 270 of about 658,368 (320)

A Cytotoxic Indazole‐based Gold(III) Carboxamide Pincer Complex Targeting DNA Through Dual Binding Modes of Groove Binding and Alkylation

Chemistry – A European Journal, EarlyView.
Toward new gold(III) anticancer agents. Herein, we report on an indazole‐based gold(III) carboxamide pincer complex exhibiting significant cytotoxicity, likely mediated through dual interactions with DNA. Mechanistic investigations suggest that the complex binds to the DNA and forms specific interactions with nucleotide bases.
Rufaro Razuwika, Sheldon Sookai, Ruth Aronson, Mandeep Kaur, Orde Q. Munro   +4 more
wiley   +1 more source

Editorial: The global phenotypic diversity of HIV-1: implications for pathogenesis, vaccine, and cure. [PDF]

Front Immunol
Bolhassani A.
europepmc   +1 more source

The Chemistry of Anticancer Mononuclear and N‐Bridged Dinuclear 8‐Aminoquinoline Half‐sandwich Metal Complexes

Chemistry – A European Journal, EarlyView.
8‐Aminoquinoline half‐sandwich metal chlorido complexes were found to undergo conversion into dimetallic analogues under basic conditions and/or by the addition of AgNO3 to abstract the chlorido ligand. In in vitro anticancer activity studies, the dimetallic complexes were found to be in general more potent than the mononuclear analogues which can be ...
Tasha R. Steel, Julia Stjärnhage, Mie Riisom, Hugh O. Bloomfield, Caitlin D. Herbert, Stephen M. F. Jamieson, Jonathan W. Astin, Tilo Söhnel, Christian G. Hartinger   +8 more
wiley   +1 more source

Immunological and Toxicological Assessment of Triterpenoid Saponins Bearing Lewis‐X‐ and QS‐21‐Based Trisaccharides

Chemistry – A European Journal, EarlyView.
The synthesis of betulinic acid and echinocystic acid saponins featuring QS‐21 minimal immunogenic motif is reported. These chimeric saponins, together with previously synthesized Lewis‐X‐containing triterpenoid saponins and a rhamnose‐modified saponin, were assessed for their toxicological and immunological profiles in wild‐type and/or hDC‐SIGN ...
Oscar Javier Gamboa Marin, Yasmine Adda‐Bouchard, Balla Sylla, Nitish Verma, Tania Charpentier, Maya Huber, Guillaume Lopez, André Pichette, Alain Lamarre, Charles Gauthier   +9 more
wiley   +1 more source

Current methods for detecting and assessing HIV-1 antibody resistance. [PDF]

Front Immunol
Odidika S, Pirkl M, Lengauer T, Schommers P.   +3 more
europepmc   +1 more source

SEC‐SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded‐Over Conformations

Cytoskeleton, EarlyView.
ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes.
Kyle P. Smith, Srinivas Chakravarthy, Amit Rahi, Manas Chakraborty, Kristen M. Vosberg, Marco Tonelli, Maximilian G. Plach, Arabela A. Grigorescu, Joseph E. Curtis, Dileep Varma   +9 more
wiley   +1 more source

The utility of integrating nanopore sequencing into routine HIV-1 drug resistance surveillance. [PDF]

Microb Genom
Lule DB, Ssemwanga D, Kaleebu P, Tully DC.   +3 more
europepmc   +1 more source

Lamellarin D Acts as an Inhibitor of Type I Collagen Production

ChemMedChem, EarlyView.
COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno, Noriho Sakamoto, Hideki Hayashi, Tsutomu Fukuda, Yoshiko Akiyama, Chiaki Iketani, Ritsuko Murakami, Takatomo Tokito, Takuto Miyamura, Hirokazu Yura, Takashi Kido, Hiroshi Ishimoto, Shinnosuke Takemoto, Takahiro Takazono, Tomoya Nishino, Yuji Ishimatsu, Jun Ishihara, Kohsuke Takeda, Yoshimasa Tanaka, Hiroshi Mukae   +19 more
wiley   +1 more source

Host RNA-Binding Proteins as Regulators of HIV-1 Replication. [PDF]

Viruses
Giraldo-Ocampo S, Valiente-Echeverría F, Soto-Rifo R.   +2 more
europepmc   +1 more source

Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”

ChemMedChem, EarlyView.
This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley   +1 more source