Results 271 to 280 of about 707,804 (298)
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Clinics in Laboratory Medicine, 2002
In most infected individuals, HIV-1 replicates high levels throughout the duration of infection, including the clinically quiescent phase of disease. The level of this active viral replication correlates directly with disease progression and survival.
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In most infected individuals, HIV-1 replicates high levels throughout the duration of infection, including the clinically quiescent phase of disease. The level of this active viral replication correlates directly with disease progression and survival.
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Clinics in Laboratory Medicine, 2002
The HIV-1 is a formidable pathogen with establishment of a persistent infection based on the ability to integrate the proviral genome into chronically infected cells, and by the rapid evolution made possible by a high mutation rate and frequent recombination during the viral replication.
Monique R, Ferguson +3 more
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The HIV-1 is a formidable pathogen with establishment of a persistent infection based on the ability to integrate the proviral genome into chronically infected cells, and by the rapid evolution made possible by a high mutation rate and frequent recombination during the viral replication.
Monique R, Ferguson +3 more
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Nature Medicine, 2003
Despite considerable advances in HIV science in the past 20 years, the reason why HIV-1 infection is pathogenic is still debated and the goal of eradicating HIV-1 infection remains elusive. A deeper understanding of the interplay between HIV-1 and its host and why simian immunodeficiency virus (SIV) is nonpathogenic in some natural hosts may provide a ...
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Despite considerable advances in HIV science in the past 20 years, the reason why HIV-1 infection is pathogenic is still debated and the goal of eradicating HIV-1 infection remains elusive. A deeper understanding of the interplay between HIV-1 and its host and why simian immunodeficiency virus (SIV) is nonpathogenic in some natural hosts may provide a ...
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Journal of Infection, 2002
In this review, we address recent advances in the understanding of the pathogenesis of human immunodeficiency type 1 virus infection, which have provided the rationale for present trials of therapeutic vaccines. We shall relate this work to lessons of the past few years both in the use of highly active antiretroviral therapy to attempt eradication of ...
S, Kinloch-de Loes, B, Autran
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In this review, we address recent advances in the understanding of the pathogenesis of human immunodeficiency type 1 virus infection, which have provided the rationale for present trials of therapeutic vaccines. We shall relate this work to lessons of the past few years both in the use of highly active antiretroviral therapy to attempt eradication of ...
S, Kinloch-de Loes, B, Autran
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The Lancet, 1999
This article notes that despite advances made in the prevention and treatment of the infection perinatal transmission continues in developed and developing countries. The author discusses: mother-to-child transmission antiretroviral prevention regimens cesarean section other interventions prevention of postpartum transmission other routes of ...
D N, Burns, L M, Mofenson
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This article notes that despite advances made in the prevention and treatment of the infection perinatal transmission continues in developed and developing countries. The author discusses: mother-to-child transmission antiretroviral prevention regimens cesarean section other interventions prevention of postpartum transmission other routes of ...
D N, Burns, L M, Mofenson
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Obstetrics and Gynecology Clinics of North America, 1997
Although there is optimism that with the prospective identification and treatment of HIV-1-infected pregnant women the incidence of pediatric infection can be diminished, currently the number of HIV-1-infected children continues to rise. Improvements in early diagnosis provide the potential for early intervention, and the advent of more potent ...
A J, Melvin, L M, Frenkel
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Although there is optimism that with the prospective identification and treatment of HIV-1-infected pregnant women the incidence of pediatric infection can be diminished, currently the number of HIV-1-infected children continues to rise. Improvements in early diagnosis provide the potential for early intervention, and the advent of more potent ...
A J, Melvin, L M, Frenkel
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Clinics in Laboratory Medicine, 2002
Morbidity and mortality associated with HIV infection increased rapidly following the recognition of this syndrome in 1981, and by 1994, AIDS was the leading cause of death in the United States among men and women ages 15-45. The antiretroviral therapy era began in 1987 following the Food and Drug Administration approval of zidovudine, a nucleoside ...
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Morbidity and mortality associated with HIV infection increased rapidly following the recognition of this syndrome in 1981, and by 1994, AIDS was the leading cause of death in the United States among men and women ages 15-45. The antiretroviral therapy era began in 1987 following the Food and Drug Administration approval of zidovudine, a nucleoside ...
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Expert Opinion on Therapeutic Targets, 2001
Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith +2 more
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Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith +2 more
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The Lancet, 2007
Taiwan is entering a new and dangerous phase of its HIV-1/AIDS epidemic. By the end of 2006 13 702 individuals (including 599 foreigners) had been reported as infected with HIV-1 to the Centers for Disease Control of Taiwan. In 2003 HIV-1 rates in first-time blood donors military conscripts and pregnant women were measured at 5.2 57.0 and 12.0 per 100 ...
Yi-Ming Arthur, Chen +1 more
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Taiwan is entering a new and dangerous phase of its HIV-1/AIDS epidemic. By the end of 2006 13 702 individuals (including 599 foreigners) had been reported as infected with HIV-1 to the Centers for Disease Control of Taiwan. In 2003 HIV-1 rates in first-time blood donors military conscripts and pregnant women were measured at 5.2 57.0 and 12.0 per 100 ...
Yi-Ming Arthur, Chen +1 more
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