Results 271 to 280 of about 658,368 (320)

An Efficient Solid‐Phase Synthetic Approach to Prepare TACN‐Functionalized Peptides

Chemistry–Methods, EarlyView.
By recruiting fluorescent dye NBD as a protecting group, Bis‐NBD‐NO1A is developed as a universal building block to functionalize peptides with TACN derivatives via SPPS. The protection of TACN with NBD becomes the first example to functionalize TACN in a controllable manner. The colour‐guided deprotection of NBD enables further elaborations of TACN as
Yik‐Hoi Yeung, Pak‐Lun Lam, Waygen Thor, Hei‐Yui Kai, Tsz‐Lam Cheung, Yue Wu, Ga‐Lai Law, Nicholas J. Long, Ka‐Leung Wong   +8 more
wiley   +1 more source

Transposable elements may enhance antiviral resistance in HIV-1 elite controllers. [PDF]

Genome Biol
Singh M, Leddy SM, Iñiguez LP, Bendall ML, Nixon DF, Feschotte C.   +5 more
europepmc   +1 more source

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir. [PDF]

PLoS Pathog
Huang SW, Briganti L, Annamalai AS, Greenwood J, Shkriabai N, Haney R, Armstrong ML, Wempe MF, Singh SP, Francis AC, Engelman AN, Kvaratskhelia M.   +11 more
europepmc   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy

ChemPlusChem, Accepted Article.
The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

HIV-1 Integrase T218I/S Polymorphisms Do Not Reduce HIV-1 Integrase Inhibitors' Phenotypic Susceptibility. [PDF]

AIDS Res Hum Retroviruses
Rodríguez-López ER, López P, Rodríguez Y, Sánchez R, Acevedo VS, Encarnación J, Tirado G, Ortiz-Sánchez C, Mesplède T, Rivera-Amill V.   +9 more
europepmc   +1 more source

Inhibition of OATP1B1/3 Rather Than UGT1A1 May Be the Major Cause of the Bilirubin Elevation After Atazanavir Administration

Clinical Pharmacology &Therapeutics, EarlyView.
Atazanavir has been reported to increase total serum bilirubin level up to ninefold. It is widely believed that the observed total bilirubin elevation is primarily due to UGT1A1 inhibition. However, UGT enzymes are well‐known as a low‐affinity and high‐capacity system, and the observed drug–drug interaction mediated by UGTs is usually less than twofold.
Jin Dong, Pradeep Sharma, Rasha Emara, Derek Cheung, Weifeng Tang, Diansong Zhou, David W. Boulton, Mats Någård, Miki S. Park   +8 more
wiley   +1 more source

Tuberculous Osteomyelitis of the Scapular Spine Revealing HIV-1 Infection. [PDF]

Trop Med Infect Dis
Idsaid K, Idalene M, Danaoui K, Ait Driss W, Elfargani R, Soraa N, Tassi N.   +6 more
europepmc   +1 more source

Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years

Clinical Pharmacology &Therapeutics, EarlyView.
Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation. [PDF]

Nature
Stacey JCV, Hrebík D, Nand E, Shetty SD, Qu K, Boicu M, Anders-Össwein M, Uchil PD, Dick RA, Mothes W, Kräusslich HG, Müller B, Briggs JAG.   +12 more
europepmc   +1 more source

Family's socioeconomic and demographic factors on elements of children's dental and oral health: A scoping review

Clinical and Experimental Dental Research, EarlyView.
Abstract Background Family plays a significant role in children's dental and oral health (DOH) elements, such as children's DOH knowledge and practice, the development of children's dental fear and anxiety (DFA), children's dental visits, and children's DOH status.
Wisnu Fadila, Mugia B. Rahardja, Puguh Prasetyoputra, Anne A. Suwargiani, Yanu E. Prasetyo, Eriska Riyanti   +5 more
wiley   +1 more source