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The term “virus maturation” in general refers to alterations of the architecture of a virus that occur after the particle with all its constituents has been formed. In the case of HIV-1 and other retroviruses, maturation involves cleavage of the main structural polyprotein, Gag, by the virusencoded protease once the immature virion is released from the
Barbara Müller, Hans-Georg Kräusslich
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Current Infectious Disease Reports, 1999
The success of antiretroviral therapy for HIV-1 infection has generated interest in mechanisms by which the virus can persist in the body despite the presence of drugs that effectively inhibit key steps in the virus life cycle. There are several potential cellular and anatomic reservoirs for HIV-1.
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The success of antiretroviral therapy for HIV-1 infection has generated interest in mechanisms by which the virus can persist in the body despite the presence of drugs that effectively inhibit key steps in the virus life cycle. There are several potential cellular and anatomic reservoirs for HIV-1.
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A Patient with HIV-1 Superinfection
New England Journal of Medicine, 2002An HIV-1–infected patient had a rebound in viremia when antiviral therapy was discontinued as part of a vaccine research protocol. Careful studies showed that this patient was infected initially with subtype AE of the virus but then became infected with subtype B.
Jost, Stéphanie+8 more
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Th1 and th2 responses, HIV-1 coreceptors, and HIV-1 infection.
Journal of biological regulators and homeostatic agents, 2001The Th1/Th2 model provides an interesting paradigm for understanding several pathophysiological processes and possibly for developing new immunotherapeutical strategies. In HIV-1 infection the interaction between the type of HIV-1 strain and the pathway of the ongoing T-cell effector response, despite its complexity, may represent one of the crucial ...
G. GALLI+5 more
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2007
Publisher Summary This chapter discusses the possible roles for RNA interference (RNAi) in the human immunodeficiency virus type 1 (HIV‐1) life cycle and the way in which HIV‐1 might use protein and RNA elements to regulate RNA‐based viral restriction. RNAi can regulate a variety of biological processes.
Le, S, Yeung, ML, Bennasser, Y, Jeang, K
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Publisher Summary This chapter discusses the possible roles for RNA interference (RNAi) in the human immunodeficiency virus type 1 (HIV‐1) life cycle and the way in which HIV‐1 might use protein and RNA elements to regulate RNA‐based viral restriction. RNAi can regulate a variety of biological processes.
Le, S, Yeung, ML, Bennasser, Y, Jeang, K
openaire +5 more sources