Results 211 to 220 of about 42,534 (266)

<i>N</i>-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants. [PDF]

ACS Infect Dis
Mahajan PS, Smith SJ, Li M, Craigie R, Hughes SH, Zhao XZ, Burke TR.   +6 more
europepmc   +1 more source

Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK

, 2010
Steven P. Tanis, Michael Plewe, Ted W. Johnson, Scott L. Butler, Deepak Dalvie, Dorothy M. DeLisle, Klaus Dress, Qiyue Hu, Buwen Huang, Jon Kuehler, Atsuo Kuki, Wen Liu, Qinghai Peng, Graham L. Smith, Jim Solowiej, Khanh Tran, Hai Wang, Anle Yang, Chunfeng Yin, Xiaoming Yu, Junhu Zhang, Huichun Zhu   +21 more
openalex   +1 more source

An improved lentivirus vector for safer transgene integration and protein transduction [PDF]

Schenkwein, Diana
core  

Elucidating the Molecular Determinants of the Binding Modes of a Third-Generation HIV-1 Integrase Strand Transfer Inhibitor: The Importance of Side Chain and Solvent Reorganization. [PDF]

Viruses
Sun Q, Biswas A, Lyumkis D, Levy R, Deng N.   +4 more
europepmc   +1 more source

LEDGF/p75 is a novel cellular interactor of HIV-1 integrase, essential for its stability and nuclear accumulation in human cells [PDF]

, 2003
Peter Cherepanov, Goedele N. Maertens, Katrien Busschots, Yves Engelborghs, Erik De Clercq, Zeger Debyser   +5 more
openalex  

Computational Structure-based Design Approaches: Targeting HIV-1 Integrase and the Macrophage Infectivity Potentiator of Legionella pneumophila

, 2010
Martin Sippel
openalex   +1 more source

Discovery of HIV-1 Integrase Inhibitors

Discovery of HIV-1 Integrase Inhibitors
openaire  

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Targeting HIV-1 integrase

Expert Opinion on Therapeutic Targets, 2001
Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith, Gilles, Sauvé, Jocelyn, Yelle   +2 more
openaire   +2 more sources

Thiazolothiazepine Inhibitors of HIV-1 Integrase

Journal of Medicinal Chemistry, 1999
A series of thiazolothiazepines were prepared and tested against purified human immunodeficiency virus type-1 integrase (HIV-1 IN) and viral replication. Structure-activity studies reveal that the compounds possessing the pentatomic moiety SC(O)CNC(O) with two carbonyl groups are in general more potent against purified IN than those containing only one
NEAMATI N., TURPIN J. A, WINSLOW H. E., CHRISTENSEN J. L., WILLIAMSON K., ORR A., RICE W. G., POMMIER Y., GAROFALO A., BRIZZI A., CAMPIANI G., FIORINI I., NACCI V.   +12 more
openaire   +4 more sources

Hydrazide-Containing Inhibitors of HIV-1 Integrase

Journal of Medicinal Chemistry, 1997
Inhibitors of HIV integrase are currently being sought as potential new therapeutics for the treatment of AIDS. A large number of inhibitors discovered to date contain the o-bis-hydroxy catechol structure. In an effort to discover structural leads for the development of new HIV integrase inhibitors which do not rely on this potentially cytotoxic ...
H, Zhao, N, Neamati, S, Sunder, H, Hong, S, Wang, G W, Milne, Y, Pommier, T R, Burke   +7 more
openaire   +2 more sources