Results 101 to 110 of about 726,640 (329)

Interventions for neurocognitive dysfunction [PDF]

, 2017
Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core   +2 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Infectious outcomes of a standardized subcutaneous immunoglobulin dose reduction strategy in primary immune deficiencies amid global shortage

Frontiers in Immunology
IntroductionImmunoglobulin replacement therapy (IgRT), either intravenous (IVIg) or subcutaneous (SCIg), is crucial for managing primary immune deficiencies (PIDs) with hypogammaglobulinemia by reducing infection rates and mortality.
Pedro Moral Moral, Pedro Moral Moral, Marta Dafne Cabanero-Navalon, Marta Dafne Cabanero-Navalon, Paula Teresa López-León, Paula Teresa López-León, Héctor Balastegui-Martín, Héctor Balastegui-Martín, Sandra Martínez Mercader, Sandra Martínez Mercader, Amparo Mir, Victor Garcia-Bustos, Victor Garcia-Bustos, Victor Garcia-Bustos   +13 more
doaj   +1 more source

The clinical effectiveness of individual behaviour change interventions to reduce risky sexual behaviour after a negative human immunodeficiency virus test in men who have sex with men: systematic and realist reviews and intervention development [PDF]

, 2017
Background: Men who have sex with men (MSM) experience significant inequalities in health and well-being. They are the group in the UK at the highest risk of acquiring a human immunodeficiency virus (HIV) infection.
Abraham, Aghaizu, Ajzen, Albarracín, Angus, Bailey, Bandura, Bartholomew, Becker, Bedoya, Berg, Berg, Berg, Blas, Borrelli, Borrelli, Bourne, Bourne, Bourne, Bowen, Bowen, Brady, British Association for Sexual Health & HIV, Brown, Bull, Cane, Carey, Carpenter, Carrico, Centers for Disease Control and Prevention, Chesney, Chiasson, Christensen, ClincalTrials.gov, ClincalTrials.gov, ClincalTrials.gov, Clutterbuck, Coffin, Cohen, Coia, Colfax, Conner, Craig, Crepaz, Crepaz, Das, Davidovich, Davidovich, DerSimonian, Desai, Dilley, Dilley, Dilley, Dilley, Dixon-Woods, Duan, Eaton, Eaton, Eaton, Elford, Ellis, European Centre for Disease Prevention and Control, Fisher, Fisher, Fletcher, Flowers, Flowers, Flowers, Flowers, Flowers, Forney, Frasca, French, Gardner, Gilbart, Glanz, Gold, Goodwin, Grantome, Gray, Guo, Hao, Health Protection Scotland, Herbst, Hidalgo, Higa, Higgins, Hightow-Weidman, Hightow-Weidman, Hirshfield, Hoaglin, Hosek, Hosek, Hosek, Huan, Hughes, Imrie, Janis, Jansen, Janz, Jbilou, Johnson, Johnson, Johnson, Johnson, Johnson, Jones, Kalichman, Kasatpibal, Kayser, Khosropour, Knussen, Ko, Koblin, Koblin, Landovitz, Lau, Lau, Lawson, Lorimer, Lu, Lucas, Macdonald, Malek, May, May, McKee, Melendez-Torres, Menza, Metcalf, Metcalf, Metsch, Michie, Michie, Michie, Michie, Michie, Mikolajczak, Mikolajczak, Mikolajczak, Miller, Mimiaga, Miranda, Moher, Morgenstern, Morgenstern, Murray, Mustanski, Mustanski, Nakagawa, Nakagawa, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, Neumann, New South Wales Sexually Transmitted Infection Program Unit, NHS Healthcare Improvement Scotland, Noar, Noar, Olander, Operario, Outlaw, O’Donnell, Painter, Parsons, Pawson, Pawson, Pawson R, Phillips, Picciano, Picciano, Prestwich, Public Health England, Rashbrook, Read, Reback, Rees, Reeves, Rhodes, Rhodes, Robinson, Rosser, Rycroft-Malone, Safren, Santos, Schnall, Schwarzer, Shoptaw, Shoptaw, Shoptaw, Simms, Simms, Skarbinski, Strömdahl, Tan, Taylor, Tobin, Tracy, van Kesteren, Varney, Warner, Webb, Wilkerson, Williams, Williams, Wolfers, Wolitski, Wong, Ye, Yin, Young, Young, Zhang, Zule   +213 more
core   +3 more sources

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

In vitro Infection of Primary Human Monocytes with HIV-1

Bio-Protocol, 2019
Monocyte infection by HIV-1 is an important component of chronic HIV pathogenesis. Following infection by HIV-1, monocytes are able to cross the blood brain barrier and set up a viral reservoir in the central nervous system.
Patrick O’Connell, Yong-Hui Zheng, Andrea Amalfitano, Yasser Aldhamen   +3 more
doaj   +1 more source

Male circumcision and HIV infection in Swaziland: is there an association? [PDF]

, 2013
Thesis (M.A.)--University of the Witwatersrand, Demography and Population Studies, 2013Background: HIV/AIDS is the leading cause of death among sexually active adults in SSA. In Swaziland, HIV prevalence is the highest in the world.
Machava, Richard Owen
core  

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

HIV controllers: hope for a functional cure

Frontiers in Immunology
Elite controllers (ECs) and post-treatment controllers (PTCs) represent important models for achieving a functional cure for HIV. This review synthesizes findings from immunological, genetic, and virological studies to compare the mechanisms underlying ...
Zhuoya Deng, Zhuoya Deng, Hongxia Yan, Hongxia Yan, Olivier Lambotte, Christiane Moog, Christiane Moog, Bin Su, Bin Su, Bin Su   +9 more
doaj   +1 more source