Results 81 to 90 of about 2,485,203 (260)

Breast Milk from Tanzanian Women has Divergent Effects on Cell-Free and Cell-Associated HIV-1 Infection in Vitro. [PDF]

, 2012
Transmission of HIV-1 during breastfeeding is a significant source of new pediatric infections in sub-Saharan Africa. Breast milk from HIV-positive mothers contains both cell-free and cell-associated virus; however, the impact of breast milk on HIV-1 ...
Ruth I Connor, Alexandra L Howell, Molly L Housman, Lee, F.V, Housman, M.L., Zain-Ul-Abideen Muhammad, Frederick V Lee, Zain-Ul-Abideen, M., Connor, R.I, Connor Ruth I., Zain-Ul-Abideen, Muhammad, Lyimo, M.A., Howell, Alexandra L, Lyimo, Magdalena A, Magdalena A Lyimo, Howell Alexandra L., Housman, Molly L, Mosi, M.N, Muhammad Zain-Ul-Abideen, Howell, A.L, Lee, Frederick V, Mosi, Matilda Ngarina, Matilda Ngarina Mosi, Connor, Ruth I, Lyimo Magdalena A., Housman Molly L., Mosi Matilda Ngarina, Lee Frederick V.   +27 more
core   +2 more sources

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Overestimating HIV infection: [PDF]

In the absence of HIV testing, how do rural Malawians assess their HIV status? In this paper, we use a unique dataset that includes respondents’ HIV status as well as their subjective likelihood of HIV infection. These data show that many rural Malawians
Hans-Peter Kohler, Philip Anglewicz
core  

Non-consensual sex and association with incident HIV infection among women: A cohort study in rural Uganda 1990-2008 [PDF]

, 2012
Non-consensual sex is associated with HIV infection in Africa, but there is little longitudinal data on this association. We describe reported non-consensual sex among women over two decades in southwest Uganda, including associations with incident HIV ...
Floyd, Sian, Seeley, Janet, Weiss, Helen A, Janet Seeley, Helen A. Weiss, Maher, Dermot, Mayanja, Billy N, Isolde Birdthistle, Birdthistle, Isolde, Mayanja, Billy N., Weiss, Helen A., Billy N. Mayanja, Dermot Maher, Sian Floyd   +13 more
core   +1 more source

Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial

BMC Pediatrics, 2018
Background HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans ...
R. Chingono, H. Mebrahtu, Z. Mupambireyi, V. Simms, H. A. Weiss, P. Ndlovu, F. Charasika, M. Tomlinson, L.D. Cluver, F. M. Cowan, L. Sherr   +10 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Trends in HIV & syphilis prevalence and correlates of HIV infection: results from cross-sectional surveys among women attending ante-natal clinics in Northern Tanzania. [PDF]

, 2010
BACKGROUND: Sentinel surveillance for HIV in ante-natal clinics (ANC) remains the primary method for collecting timely trend data on HIV prevalence in most of sub-Saharan Africa.
Slaymaker Emma, Mngara Julius, Changalucha John, Urassa, Mark, Kimaro Daniel, Isingo, Raphael, Julius Mngara, Isingo Raphael, Urassa Mark, Changalucha, John, Zaba Basia, John Changalucha, Mark Urassa, Daniel Kimaro, Zaba, Basia, Mngara, Julius, Kimaro, Daniel, Yusufu Kumogola, Mwidunda, Patrick, Emma Slaymaker, Mwidunda Patrick, Kumogola Yusufu, Raphael Isingo, Slaymaker, Emma, Kumogola, Yusufu, Patrick Mwidunda, Basia Zaba   +26 more
core   +2 more sources

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Is the HCV-HIV co-infection prevalence amongst injecting drug users a marker for the level of sexual and injection related HIV transmission?

, 2013
BACKGROUND: Amongst injecting drug users (IDUs), HIV is transmitted sexually and parenterally, but HCV is transmitted primarily parenterally. We assess and model the antibody prevalence of HCV amongst HIV-infected IDUs (denoted as HCV-HIV co-infection ...
?, ?, Martin, Natasha K, Strathdee, Steffanie, Beattie, Tara, Vickerman, Peter, EMCDDA Collaborative Group, Jarlais, Don Des, Wiessing, Lucas, Roy, Anuradha, Hickman, Matthew   +9 more
core   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source