Results 171 to 180 of about 2,485,203 (260)

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

Isolating T‐Cell Potent Lentiviral Vector Subpopulations through Rational Design of Nanofiber Anion‐Exchange Adsorbents

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Generation of CAR‐T cell therapies relies predominantly on lentiviral vectors (LVs). As in vivo CAR‐T trials progress, demand for larger quantities of higher‐potency LV is expected. However, primary capture by anion‐exchange chromatography (AIEX) remains a major manufacturing bottleneck from use of adsorbents not tailored to LVs, leading to ...
George Pamenter, Gyorgy Ovari, Anurag Kulkarni, Thomas Williams‐Fegredo, Carol Knevelman, Kyriacos Mitrophanous, Lee Davies, Farzad Foroutan, Matthew Townsend, Stephen Goldrick, Daniel G. Bracewell   +10 more
wiley   +1 more source

sVCAM-1 and Hematological Profiles Are Associated With CD4-Defined Disease Status in HIV Infection. [PDF]

J Med Virol
Almeida-Silva B, da Silva-Junior CD, Vaitkevicius-Antão V, Aciole MR, Márcia da Silva M, Rocha Vilela Moura LC, Ramos de Araujo PS, Christiane da Silva Rabello M, Barros de Lorena VM.   +8 more
europepmc   +1 more source

A British Pharmacological Society Position Statement on Medications in Pregnancy and Lactation

British Journal of Clinical Pharmacology, EarlyView.
Agnesa Mustafa, Cleodie C. Swire, Reya V. Shah, Bernadette Jenner, Rory H. McLean, Muhammad Shamsher Ahmed, Adrie Bekker, Julia Zöllner, Rachel K. Scott, Robert R. Bies, Sara K. Quinney, Dagan O. Lonsdale, Emma Forton Magavern, Catriona Waitt, Anita Banerjee   +14 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Giant condyloma acuminatum in a patient with HIV infection: a case report. [PDF]

AIDS Res Ther
Wang C, Wang T, Gao L, Zhang Y, Liu Y, Jia G, Zhao Z, Li J, Kang W.   +8 more
europepmc   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Advances in Immune-Based Approaches for the Cure of HIV Infection. [PDF]

Drugs
Wagner JA, Sandel DA, Deitchman AN, Rutishauser RL, Deeks SG, Peluso MJ.   +5 more
europepmc   +1 more source

A Closer Look at Rape Myth Beliefs Among University Students: Comparisons and Correlates Based on Field and Stage of Study, Victimisation Experiences, Demographics and Psychological Traits

Behavioral Sciences &the Law, EarlyView.
ABSTRACT Disproportionate rates of sexual violence occur among university students, with rape culture and misconceptions about consent prevalent. To comprehensively examine rape myth beliefs among different student groups, 417 UK University students enrolled on courses in four distinct disciplinary areas; social sciences (n = 131), applied sciences (n =
Dominic Willmott, Mairi Johnston, B. Kennath Widanaralalage, Dara Mojtahedi, Daniel Boduszek, Danielle McDermott, Gillian Kirkman   +6 more
wiley   +1 more source

Not Tuberculosis After All: The "Hare-Raising Case" of Tularemia in a Patient With Advanced HIV Infection. [PDF]

Case Rep Infect Dis
Geerdink JX, Welzen BJV.
europepmc   +1 more source