Results 31 to 40 of about 1,287,797 (309)

National Multi-Sectoral Strategic Framework on HIV/AIDS 2003 - 2007 [PDF]

, 2003
Tanzania is facing a major threat to the survival of its people and the development chances of the nation from a concentrated and generalised HIV /AIDS epidemic. More than two Million people are estimated to be living with HIV /AIDS in 2002.
Tanzania Commission for HIV/AIDS, (TCAIDS)
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Poor post‐exposure prophylaxis completion despite improvements in post‐violence service delivery in 14 PEPFAR‐supported sub‐Saharan African countries, 2018–2023

Journal of the International AIDS Society
Introduction Sexual violence (SV) affects millions globally and has a well‐documented bidirectional association with HIV. Post‐exposure prophylaxis (PEP) is a critical, yet often underutilized, HIV prevention tool in post‐SV care.
Udhayashankar Kanagasabai, Stephanie M. Davis, Viva Thorsen, Emily Rowlinson, Anne Laterra, Jennifer Hegle, Carrine Angumua, Alexandre Ekra, Minlangu Mpingulu, Meklit Getahun, Fikirte Sida, Phumzile Mndzebele, Caroline Kambona, Puleng Ramphalla, Eunice Mtingwi, Wezi Msungama, Meghan Duffy, Bukola Adewumi, Ezeomu Olotu, Jackson Sebeza, Jane Kitalile, Rose Apondi, Carlos Muleya, Meagan Cain   +23 more
doaj   +1 more source

Transcriptional landscape of Kaposi sarcoma tumors identifies unique immunologic signatures and key determinants of angiogenesis

Journal of Translational Medicine, 2023
Background Kaposi sarcoma (KS) is a multicentric tumor caused by Kaposi sarcoma herpesvirus (KSHV) that leads to morbidity and mortality among people with HIV worldwide.
Ramya Ramaswami, Takanobu Tagawa, Guruswamy Mahesh, Anna Serquina, Vishal Koparde, Kathryn Lurain, Sarah Dremel, Xiaofan Li, Ameera Mungale, Alex Beran, Zoe Weaver Ohler, Laura Bassel, Andrew Warner, Ralph Mangusan, Anaida Widell, Irene Ekwede, Laurie T. Krug, Thomas S. Uldrick, Robert Yarchoan, Joseph M. Ziegelbauer   +19 more
doaj   +1 more source

Validation of replicative phenotyping to detect and assign HIV-1 resistance in clinical specimens [PDF]

, 2009
The ability of HIV-1 to develop resistance to antiretroviral drugs has limited the overall efficacy of combination therapy to suppress viral replication.
Louvel, Séverine
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The impact of lookback windows on the prevalence and incidence of chronic diseases among people living with HIV: an exploration in administrative health data in Canada

BMC Medical Research Methodology, 2022
Background We described the impact of different lengths of lookback window (LW), a retrospective time period to observe diagnoses in administrative data, on the prevalence and incidence of eight chronic diseases.
Ni Gusti Ayu Nanditha, Xinzhe Dong, Taylor McLinden, Paul Sereda, Jacek Kopec, Robert S. Hogg, Julio S. G. Montaner, Viviane D. Lima   +7 more
doaj   +1 more source

Anti-HIV Effects of HIV Vectors

Virology, 1998
We have recently developed an HIV-1 packaging cell line, psi 422, as an improved tool for anti-HIV gene therapy. After stable transfection with an HIV-1 or HIV-2 vector, psi 422 has been shown to synthesize virions able to transduce CD4+ T cells and macrophages.
Corbeau, Pierre, Wong-Staal, Flossie
openaire   +2 more sources

Women and HIV [PDF]

BMC Women's Health, 2004
HEALTH ISSUE: The epidemic of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) in developed countries has changed from the early epidemic that affected primarily men who have sex with men, to one that increasingly affects other groups such as injecting drug users (IDU) and heterosexuals.
Gatali, Marene, Archibald, Chris
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source