Results 31 to 40 of about 1,322,023 (308)

The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations. [PDF]

, 2013
We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C),
C Leen, Samuel, M., Chadwick, D, Gompels, Mark, Johnson, M., Anderson, Jane, Leen, Clifford, Samuel, M, Fisher, M., Pillay, Deenan, Orkin, Chloe, Sabin, C, Hay, Phillip, Johnson, M, CA Sabin, M Fisher, Nelson, M., M Johnson, S Jose, Gilson, Richard, Fisher, M, Ainsworth, Jonathan, ?, ?, Johnson, Margaret, Gilson, R, Sabin, C. A., Hay, P, D Chadwick, Gompels, M, R Gilson, Sabin, Ca, Nelson, Mark, UK Collaborative HIV Cohort Study, Palfreeman, Adrian, P Hay, Delpech, Valerie, Fisher, Martin, FA Post, Babiker, Abdel, UK Collaborative HIV Cohort Study (UK CHIC), Chadwick, David, Hay, P., Kegg, Stephen, M Samuel, Gilson, R., Gompels, M., Sachikonye, Memory, Nelson, M, Winston, A, Post, Fa, A Winston, Leen, C., Gazzard, Brian, Post, F A, Jose, S., Post, Frank, M Nelson, Jose, S, Post, F, Chadwick, D., Sabin, C A, Leen, C, Winston, A., M Gompels   +63 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Anti-HIV Effects of HIV Vectors

Virology, 1998
We have recently developed an HIV-1 packaging cell line, psi 422, as an improved tool for anti-HIV gene therapy. After stable transfection with an HIV-1 or HIV-2 vector, psi 422 has been shown to synthesize virions able to transduce CD4+ T cells and macrophages.
Corbeau, Pierre, Wong-Staal, Flossie
openaire   +2 more sources

Women and HIV [PDF]

BMC Women's Health, 2004
HEALTH ISSUE: The epidemic of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) in developed countries has changed from the early epidemic that affected primarily men who have sex with men, to one that increasingly affects other groups such as injecting drug users (IDU) and heterosexuals.
Gatali, Marene, Archibald, Chris
openaire   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

HIV testing and HIV prevention in Sweden [PDF]

BMJ, 1998
HIV testing is central to Sweden's programme of preventing the spread of HIV infection. It has been widely promoted and encouraged on the grounds that once HIV infected people are aware of their serostatus and receive appropriate counselling, they will take the necessary steps to protect their partners.1 This faith in the inclination of citizens to ...
openaire   +2 more sources

Retention in primary care among unstably housed residents of a low-income, inner-city neighborhood with a high prevalence of substance use and related disorders

International Journal for Equity in Health
Introduction Access to and engagement with primary healthcare can be difficult for marginalized low-income populations residing in inner cities in high-income countries.
M. Gumprich, W. Zhang, J. Li, K. Salters, R. Barrios, P. Sereda, C. Stanley, R. Joe, D. Hall, V. Lima, G. Sincraian, A. Marante Changir, R. Parry, C. Fulton, T. Wesseling, J. Montaner, S. Parashar, David M. Moore   +17 more
doaj   +1 more source

Transcriptional landscape of Kaposi sarcoma tumors identifies unique immunologic signatures and key determinants of angiogenesis

Journal of Translational Medicine, 2023
Background Kaposi sarcoma (KS) is a multicentric tumor caused by Kaposi sarcoma herpesvirus (KSHV) that leads to morbidity and mortality among people with HIV worldwide.
Ramya Ramaswami, Takanobu Tagawa, Guruswamy Mahesh, Anna Serquina, Vishal Koparde, Kathryn Lurain, Sarah Dremel, Xiaofan Li, Ameera Mungale, Alex Beran, Zoe Weaver Ohler, Laura Bassel, Andrew Warner, Ralph Mangusan, Anaida Widell, Irene Ekwede, Laurie T. Krug, Thomas S. Uldrick, Robert Yarchoan, Joseph M. Ziegelbauer   +19 more
doaj   +1 more source

Molecular Signatures of HIV-Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV. [PDF]

Adv Sci (Weinh)
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Chennakesavan K, Samikkannu M, Gupta S, Tayo OI, Acharya A, Cai JJ, Byrareddy SN, Samikkannu T.   +7 more
europepmc   +2 more sources

Commercial sex and the spread of HIV in four cities in sub-Saharan Africa. [PDF]

, 2001
OBJECTIVE: To examine whether commercial sex transactions were more common and/or transmission between sex workers and clients more efficient in two African cities with high HIV prevalence (Kisumu, Kenya and Ndola, Zambia) compared with two with ...
Morison, L., Caraël, M, Weiss, HA, Kanhonou, L., Hayes, R. J., Chege, J., Buvé, A, Buvé, A., Abega, S. C., Weiss, H. A., Study Group on Heterogeneity of HIV Epidemics in African Cities, Caraël, M., Chege, J, Kanhonou, L, Abega, SC, Kaona, F., Morison, L, Kaona, F, Hayes, RJ   +18 more
core   +1 more source