Results 131 to 140 of about 314,387 (344)

Prevalence of HIV-1 transmitted drug resistance and its impact on the effectiveness of antiretroviral therapy - Minas Gerais state, Brazil / Prevalência de resistência transmitida do HIV-1 e seu impacto na efetividade da terapia antirretroviral – Minas Gerais, Brasil [PDF]

, 2022
Gabriella Jomara da Silva, Agdemir Waléria Aleixo, Unaí Tupinambás   +2 more
openalex   +1 more source

Physiologically based pharmacokinetic model combined with a clinical lactation study to determine doravirine concentrations in human breastmilk

British Journal of Clinical Pharmacology, EarlyView.
Aims To determine breastmilk concentrations of doravirine via PBPK modelling in combination with a clinical lactation study. As women living with HIV are not able to cease antiretroviral therapy during lactation, it is necessary to establish drug transfer into breastmilk to determine exposure of the infant to antiretroviral drugs and potential risk of ...
Lena van der Wekken‐Pas, David Burger, Rick Greupink, Angela Colbers   +3 more
wiley   +1 more source

HIV versus the Terminator: Drug resistance of HIV reverse transcriptase with mutations at the connection subdomain [PDF]

, 2008
only availableAntiretroviral drug therapy can prolong the life of an HIV-infected individual, but this treatment also promotes drug-resistance mutations.
Jackson, Jacob C., Sarafianos, Stefan G., Schuckmann, Matthew M.   +2 more
core  

Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe, Lufina Tsirizani, Buyisile Mkhize, Lubbe Wiesner, Gary Maartens, Francesca Conradie, Richard Court, Marian Loveday, Catriona Waitt, Paolo Denti   +9 more
wiley   +1 more source

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase [PDF]

, 2013
Peter K. Quashie, Thibault Mésplède, Ying-Shan Han, Tamar Veres, Nathan Osman, Said Hassounah, Richard D. Sloan, Hong-Tao Xu, Mark A. Wainberg   +8 more
openalex   +1 more source

HIV‐1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates [PDF]

, 2020
Soo‐Yon Rhee, Seble Kassaye, Geoffrey Barrow, Jagadish Chandrabose Sundaramurthi, Michael R. Jordan, Robert W. Shafer   +5 more
openalex   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Pan-Resistant HIV-1 Drug Resistance Among Highly Treated Patients with Virological Failure on Dolutegravir-Based Antiretroviral Therapy in Zimbabwe

Viruses
The HIV-1 epidemic continues to challenge global public health, especially in sub-Saharan Africa. The rise in drug-resistant viruses, particularly pan-resistant strains, threatens treatment effectiveness, hindering progress toward UNAIDS viral ...
Tendai Washaya, Benjamin Chimukangara, Justin Mayini, Sandra Bote, Nyasha Chin’ombe, Shungu Munyati, Justen Manasa   +6 more
doaj   +1 more source

Drug resistance from preferred antiretroviral regimens for HIV infection in South Africa: A modeling study.

PLoS ONE, 2019
BACKGROUND:Tenofovir-containing regimens comprise the preferred first-line antiretroviral therapy (ART) in many countries including South Africa, where utilization of second-line regimens is limited.
Ume L Abbas, Robert L Glaubius, Yajun Ding, Gregory Hood   +3 more
doaj   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source