Results 111 to 120 of about 308,174 (298)
HIV-1 drug mutations in children from northern Tanzania [PDF]
, 2014 Objectives: In resource-limited settings, it is a challenge to get quality clinical specimens due to poor infrastructure for their collection, transportation, processing and storage. Using dried blood spots (DBS) might be an alternative to plasma for HIV-
Shao, Elichilia R. +9 more
core +2 more sources
Advanced Intelligent Discovery, EarlyView.This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng +4 more
wiley +1 more source
Iranian Journal of Microbiology, 2022 Background and Objectives: Even after four decades, HIV infection remains a global challenge and a leading cause of mortality in adults across the world.
Dilip D. Karad +5 more
doaj
Advanced Intelligent Discovery, EarlyView.This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah +3 more
wiley +1 more source
Advances in HIV-1 resistance detection technology
Guangxi Yike Daxue xuebaoHIV has ravaged the world for more than forty years, causing great pressure on global public health. Today, AIDS is still a medical challenge for global public health.
SHEN Kuiling +3 more
doaj +1 more source
Emergence of Minor Populations of Human Immunodeficiency Virus Type 1 Carrying the M184V and L90M Mutations in Subjects Undergoing Structured Treatment Interruptions [PDF]
, 2017 The use of structured treatment interruption (STI) in human immunodeficiency virus (HIV)-infected subjects is currently being studied as an alternative therapeutic strategy for HIV-1.
Allers, Kristina +8 more
core
HIV drug resistance: problems and perspectives
Infectious Disease Reports, 2013 Access to combination antiretroviral treatment (ART) has improved greatly over recent years. At the end of 2011, more than eight million HIV-infected people were receiving ART in low-income and middle-income countries. ART generally works well in keeping the virus suppressed and the patient healthy. However, treatment only works as long as the virus is
openaire +5 more sources
New developments in HIV drug resistance [PDF]
Journal of Antimicrobial Chemotherapy, 2009 Several new antiretroviral drugs have recently been licensed for use in HIV-1-infected patients. These include drugs in two new classes: an integrase inhibitor (raltegravir) and a CCR5 co-receptor antagonist (maraviroc). In addition, two new protease inhibitors, atazanavir and darunavir, which have activity against viruses resistant to other protease ...
openaire +2 more sources
The rain feels different under the same umbrella: Experiences with poverty across LGBTQ subgroups
American Journal of Community Psychology, EarlyView.Abstract Population‐based survey data have demonstrated that LGBTQ communities report varying rates of economic insecurity, yet very little research directly assesses how pathways into and experiences with poverty look different among subgroups at the intersections of sexual orientation and gender identity (SOGI).
Bianca D. M. Wilson, Lillian Nguyen
wiley +1 more source
Loss and Recovery of Genetic Diversity in Adapting Populations of HIV [PDF]
, 2013 The evolution of drug resistance in HIV occurs by the fixation of specific, well-known, drug-resistance mutations, but the underlying population genetic processes are not well understood.
Kryazhimskiy, Sergey +2 more
core +5 more sources