Results 91 to 100 of about 308,174 (298)
Advanced Science, EarlyView.This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu +9 more
wiley +1 more source
Genetic subtypes and drug resistance in untreated patients with HIV-1 infection in Qingdao, China: An analysis of 113 cases [PDF]
精准医学杂志Objective To investigate genetic subtypes and drug resistance in untreated patients with HIV-1 infection in Qingdao. Methods A retrospective analysis was performed for the genetic subtypes, drug resistance, and other clinical data of patients with new ...
WANG Hong, LI Hongbo, SUN Chunfeng, LI Xiang, XU Guangyong
doaj +1 more source
Personalizing HIV therapy, mission impossible? [PDF]
, 2012 Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
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HIV Antiretroviral Drug Resistance [PDF]
Journal of AIDS & Clinical Research, 2013 Highly active antiretroviral therapy (HAART) is the current standard of care for human immunodeficiency virus (HIV) infections. Although drug resistance may have been present before the introduction of antiretroviral (ARV) therapy due to random genetic variation, the introduction of ARV therapy exerts selective pressure over viral subpopulations to ...
openaire +1 more source
Advanced Science, EarlyView.(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin +12 more
wiley +1 more source
The Molecular Basis of Resistance Antiretroviral Markers and Polymorphisms of the Human Immunodeficiency Virus-1 Subtype Crf01-ae Protease Gene in Naïve and Treatment Failure Patients in Bali [PDF]
, 2012 Application of antiretrovirals (ARVs) in patients with Human Immunodeficiency Virus (HIV) infection has proven to reduce mortality rates and prolong life expectancy.
Budiyanti, N. S. (N) +3 more
core
Low prevalence of hepatitis C co-infection in recently HIV-infected minority men who have sex with men in Los Angeles: a cross-sectional study. [PDF]
, 2015 BackgroundGeographic and sociodemographic characterization of hepatitis C virus (HCV) transmission amongst men who have sex with men (MSM) has been limited.
Bhattacharya, Debika +7 more
core +2 more sources
Advanced Science, EarlyView.ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley +1 more source
Structured, sparse regression with application to HIV drug resistance
, 2011 We introduce a new version of forward stepwise regression. Our modification finds solutions to regression problems where the selected predictors appear in a structured pattern, with respect to a predefined distance measure over the candidate predictors ...
Percival, Daniel +3 more
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In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. [PDF]
, 2005 Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g ...
Back, DJ +9 more
core +1 more source